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DOI	10.1126/science.abe9728
	Three-quarters attack rate of SARS-CoV-2 in the Brazilian Amazon during a largely unmitigated epidemic
	Buss L.F.; Prete C.A.; Jr.; Abrahim C.M.M.; Mendrone A.; Jr.; Salomon T.; De Almeida-Neto C.; França R.F.O.; Belotti M.C.; Carvalho M.P.S.S.; Costa A.G.; Crispim M.A.E.; Ferreira S.C.; Fraiji N.A.; Gurzenda S.; Whittaker C.; Kamaura L.T.; Takecian P.L.; Da Silva Peixoto P.; Oikawa M.K.; Nishiya A.S.; Rocha V.; Salles N.A.; De Souza Santos A.A.; Da Silva M.A.; Custer B.; Parag K.V.; Barral-Netto M.; Kraemer M.U.G.; Pereira R.H.M.; Pybus O.G.; Busch M.P.; Castro M.C.; Dye C.; Nascimento V.H.; Faria N.R.; Sabino E.C.
发表日期	2021
ISSN	0036-8075
起始页码	288
结束页码	292
卷号	371 期号:6526
英文摘要	Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spread rapidly in Manaus, the capital of Amazonas state in northern Brazil. The attack rate there is an estimate of the final size of the largely unmitigated epidemic that occurred in Manaus. We use a convenience sample of blood donors to show that by June 2020, 1 month after the epidemic peak in Manaus, 44%of the population had detectable immunoglobulin G (IgG) antibodies. Correcting for cases without a detectable antibody response and for antibody waning, we estimate a 66% attack rate in June, rising to 76% in October. This is higher than in São Paulo, in southeastern Brazil, where the estimated attack rate in October was 29%. These results confirm that when poorly controlled, COVID-19 can infect a large proportion of the population, causing high mortality. © 2021 The Authors, some rights reserved.
英文关键词	immunoglobulin G; immunoglobulin G; virus antibody; disease transmission; drug; epidemic; heterogeneity; public transport; viral disease; adolescent; adult; aged; antibody detection; antibody response; Article; behavior change; blood donor; Brazil; cohort analysis; coronavirus disease 2019; disease severity; disease transmission; epidemic; herd immunity; human; infection control; infection rate; major clinical study; mortality rate; nonhuman; priority journal; Severe acute respiratory syndrome coronavirus 2; social distancing; blood; epidemic; epidemiological monitoring; epidemiology; female; immunology; isolation and purification; male; middle aged; mortality; seroepidemiology; young adult; Amazonas [Brazil]; Brazil; Manaus; Sao Paulo [Brazil]; SARS coronavirus; Adolescent; Adult; Aged; Antibodies, Viral; Blood Donors; Brazil; COVID-19; Epidemics; Epidemiological Monitoring; Female; Humans; Immunoglobulin G; Male; Middle Aged; SARS-CoV-2; Seroepidemiologic Studies; Young Adult
语种	英语
来源期刊	Science
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/243205
作者单位	Departamento de Molestias Infecciosas e Parasitarias, Instituto de Medicina Tropical, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil; Departamento de Engenharia de Sistemas Eletrônicos, Escola Politécnica, Universidade de São Paulo, São Paulo, Brazil; Fundação Hospitalar de Hematologia e Hemoterapia do Amazonas, Manaus, Brazil; Fundação Pró-Sangue-Hemocentro de São Paulo, São Paulo, Brazil; Lab. de Investigacao Medica em Patogenese e Terapia dirigida em Onco-Imuno-Hematologia (LIM-31), Departamento de Hematologia, Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil; Fundação Hemominas-Fundação, Centro de Hematologia e Hemoterapia de Minas Gerais, Belo Horizonte, Brazil; Faculdade Ciências Médicas de Minas Gerais, Belo Horizonte, Brazil; Department of Virology and Experimental Therapy, Institute Aggeu Magalhaes, Oswaldo Cruz Foundation, Recife, Brazil; Department of Global Health and Population, Harvard T. H. Chan School of Public Health, ...
推荐引用方式 GB/T 7714	Buss L.F.,Prete C.A.,Jr.,et al. Three-quarters attack rate of SARS-CoV-2 in the Brazilian Amazon during a largely unmitigated epidemic[J],2021,371(6526).
APA	Buss L.F..,Prete C.A..,Jr..,Abrahim C.M.M..,Mendrone A..,...&Sabino E.C..(2021).Three-quarters attack rate of SARS-CoV-2 in the Brazilian Amazon during a largely unmitigated epidemic.Science,371(6526).
MLA	Buss L.F.,et al."Three-quarters attack rate of SARS-CoV-2 in the Brazilian Amazon during a largely unmitigated epidemic".Science 371.6526(2021).