气候变化领域集成服务门户(CCPortal): Stepwise pathogenic evolution of Mycobacterium abscessus

CCPortal

DOI	10.1126/science.abb8699
	Stepwise pathogenic evolution of Mycobacterium abscessus
	Bryant J.M.; Brown K.P.; Burbaud S.; Everall I.; Belardinelli J.M.; Rodriguez-Rincon D.; Grogono D.M.; Peterson C.M.; Verma D.; Evans I.E.; Ruis C.; Weimann A.; Arora D.; Malhotra S.; Bannerman B.; Passemar C.; Templeton K.; MacGregor G.; Jiwa K.; Fisher A.J.; Blundell T.L.; Ordway D.J.; Jackson M.; Parkhill J.; Floto R.A.
发表日期	2021
ISSN	0036-8075
卷号	372 期号:6541
英文摘要	Although almost all mycobacterial species are saprophytic environmental organisms, a few, such as Mycobacterium tuberculosis, have evolved to cause transmissible human infection. By analyzing the recent emergence and spread of the environmental organism M. abscessus through the global cystic fibrosis population, we have defined key, generalizable steps involved in the pathogenic evolution of mycobacteria. We show that epigenetic modifiers, acquired through horizontal gene transfer, cause saltational increases in the pathogenic potential of specific environmental clones. Allopatric parallel evolution during chronic lung infection then promotes rapid increases in virulence through mutations in a discrete gene network; these mutations enhance growth within macrophages but impair fomite survival. As a consequence, we observe constrained pathogenic evolution while person-to-person transmission remains indirect, but postulate accelerated pathogenic adaptation once direct transmission is possible, as observed for M. tuberculosis. Our findings indicate how key interventions, such as early treatment and cross-infection control, might restrict the spread of existing mycobacterial pathogens and prevent new, emergent ones. © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.
英文关键词	nitric oxide; bacterium; evolution; gene transfer; parasite transmission; pathogen; adult; allopatry; antibiotic resistance; Article; bacterial evolution; bacterial gene; bacterial transmission; bacterial virulence; bacterium isolate; cell survival; controlled study; CRISPR-CAS9 system; evolutionary adaptation; female; gene cluster; gene frequency; gene knockout; gene locus; gene mutation; gene structure; gene transfer; genetic analysis; genetic transcription; GPL gene; host susceptibility; human; human cell; in vivo study; longitudinal study; lung injury; macrophage; major clinical study; male; middle aged; molecular cloning; mouse; mycobacteriosis; Mycobacterium; Mycobacterium avium; Mycobacterium canettii; Mycobacterium tuberculosis; nonhuman; pathogenicity; phenotype; phoR gene; population density; prediction; priority journal; protein protein interaction; RNA extraction; RNA interference; SMRT sequencing; survival rate; whole genome sequencing; atypical mycobacteriosis; bacterial genome; bacterial pneumonia; communicable disease; genetic epigenesis; genetics; horizontal gene transfer; information processing; lung; microbiology; molecular evolution; mutation; Mycobacterium abscessus; reproductive fitness; virulence; Corynebacterineae; Mycobacterium abscessus; Mycobacterium tuberculosis; Communicable Diseases, Emerging; Datasets as Topic; Epigenesis, Genetic; Evolution, Molecular; Gene Transfer, Horizontal; Genetic Fitness; Genome, Bacterial; Humans; Lung; Mutation; Mycobacterium abscessus; Mycobacterium Infections, Nontuberculous; Pneumonia, Bacterial; Virulence
语种	英语
来源期刊	Science
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/243181
作者单位	Molecular Immunity Unit, University of Cambridge Department of Medicine, MRC Laboratory of Molecular Biology, Cambridge, United Kingdom; University of Cambridge, Centre for AI in Medicine, Cambridge, United Kingdom; Cambridge Centre for Lung Infection, Royal Papworth Hospital, Cambridge, United Kingdom; Wellcome Sanger Institute, Hinxton, United Kingdom; Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO, United States; Department of Biochemistry, University of Cambridge, Cambridge, CB2 1GA, United Kingdom; Scientific Computing Department, Science and Technology Facilities Council, Harwell, United Kingdom; Queen Elizabeth University Hospital, NHS Greater Glasgow & Clyde, Glasgow, United Kingdom; Newcastle University Translational and Clinical Research Institute, Institute of Transplantation, Newcastle Upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom; Department of Veterinary Medicine, University...
推荐引用方式 GB/T 7714	Bryant J.M.,Brown K.P.,Burbaud S.,et al. Stepwise pathogenic evolution of Mycobacterium abscessus[J],2021,372(6541).
APA	Bryant J.M..,Brown K.P..,Burbaud S..,Everall I..,Belardinelli J.M..,...&Floto R.A..(2021).Stepwise pathogenic evolution of Mycobacterium abscessus.Science,372(6541).
MLA	Bryant J.M.,et al."Stepwise pathogenic evolution of Mycobacterium abscessus".Science 372.6541(2021).