气候变化领域集成服务门户(CCPortal): Recurrent cortical circuits implement concentration-invariant odor coding

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DOI	10.1126/science.aat6904
	Recurrent cortical circuits implement concentration-invariant odor coding
	Bolding K.A.; Franks K.M.
发表日期	2018
ISSN	0036-8075
卷号	361 期号:6407
英文摘要	Animals rely on olfaction to find food,attract mates,and avoid predators.To support these behaviors,they must be able to identify odors across different odorant concentrations.The neural circuit operations that implement this concentration invariance remain unclear.We found that despite concentration-dependence in the olfactory bulb(OB), representations of odor identity were preserved downstream, in the piriform cortex (PCx).The OB cells responding earliest after inhalation drove robust responses in sparse subsets of PCx neurons.Recurrent collateral connections broadcast their activation across the PCx,recruiting global feedback inhibition that rapidly truncated and suppressed cortical activity for the remainder of the sniff,discounting the impact of slower, concentration-dependent OB inputs. Eliminating recurrent collateral output amplified PCx odor responses rendered the cortex steeply concentrationdependent and abolished concentration-invariant identity decoding. ©2017.
英文关键词	tetanus toxin; tetanus toxin light chain; unclassified drug; fragrance; cell; concentration (composition); inhibition; odor; olfaction; adult; animal cell; animal experiment; animal tissue; Article; concentration (parameters); controlled study; functional connectivity; mouse; nerve cell stimulation; nonhuman; olfactory bulb; olfactory discrimination; priority journal; pyriform cortex; sensory feedback; animal; odor; olfactory system; physiological feedback; physiology; pyriform cortex; smelling; Animalia; Animals; Feedback, Physiological; Mice; Odorants; Olfactory Bulb; Olfactory Pathways; Olfactory Perception; Piriform Cortex; Smell
语种	英语
来源期刊	Science
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/243086
作者单位	Department of Neurobiology, Duke University Medical School, Durham, NC, United States
推荐引用方式 GB/T 7714	Bolding K.A.,Franks K.M.. Recurrent cortical circuits implement concentration-invariant odor coding[J],2018,361(6407).
APA	Bolding K.A.,&Franks K.M..(2018).Recurrent cortical circuits implement concentration-invariant odor coding.Science,361(6407).
MLA	Bolding K.A.,et al."Recurrent cortical circuits implement concentration-invariant odor coding".Science 361.6407(2018).