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DOI	10.1126/science.8272871
	A transforming growth factor β type I receptor that signals to activate gene expression
	Bassing C.H.; Yingling J.M.; Howe D.J.; Wang T.; He W.W.; Gustafson M.L.; Shah P.; Donahoe P.K.; Wang X.-F.
发表日期	1994
ISSN	0036-8075
起始页码	87
结束页码	89
卷号	263 期号:5143
英文摘要	Transforming growth factor beta (TGF-β) is a multifunctional factor that regulates many aspects of cellular functions. TGF-β signals through a heteromeric complex of the type I and type II TGF-β receptors. However, the molecular mechanism of signal transduction by this receptor complex remains unresolved. The type II receptor belongs to a transmembrane receptor serine-threonine kinase family. A new member of this receptor family (R4) was identified and shown to be a functional TGF-β type I receptor on the basis of its ability to restore a TGF-β-induced gene response in mutant cell lines lacking endogenous type I receptor. Both ligand binding and signaling of the R4 protein were dependent on the presence of a functional type II receptor. The type I receptor has an intrinsic serine-threonine kinase activity, which was essential for signal transduction.
英文关键词	protein serine threonine kinase; transforming growth factor beta; animal tissue; article; cell mutant; gene expression; nonhuman; priority journal; rat; signal transduction; transforming growth factor receptor; Animal; Cell Line; Gene Expression Regulation; Genes, Reporter; Mutagenesis, Site-Directed; Protein-Serine-Threonine Kinases; Rats; Rats, Sprague-Dawley; Receptors, Transforming Growth Factor beta; Signal Transduction; Support, Non-U.S. Gov't; Support, U.S. Gov't, Non-P.H.S.; Support, U.S. Gov't, P.H.S.; Transfection; Transforming Growth Factor beta; Animalia
语种	英语
来源期刊	Science
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/242975
作者单位	Department of Pharmacology, Duke University Medical Center, Durham, NC 27710, United States; Pediatric Surgical Research Laboratory, Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, United States
推荐引用方式 GB/T 7714	Bassing C.H.,Yingling J.M.,Howe D.J.,et al. A transforming growth factor β type I receptor that signals to activate gene expression[J],1994,263(5143).
APA	Bassing C.H..,Yingling J.M..,Howe D.J..,Wang T..,He W.W..,...&Wang X.-F..(1994).A transforming growth factor β type I receptor that signals to activate gene expression.Science,263(5143).
MLA	Bassing C.H.,et al."A transforming growth factor β type I receptor that signals to activate gene expression".Science 263.5143(1994).