气候变化领域集成服务门户(CCPortal): Microglia modulate neurodegeneration in Alzheimer's and Parkinson's diseases

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DOI	10.1126/science.abb8587
	Microglia modulate neurodegeneration in Alzheimer's and Parkinson's diseases
	Bartels T.; De Schepper S.; Hong S.
发表日期	2020
ISSN	0036-8075
卷号	370 期号:6512
英文摘要	Dementia is a rapidly rising global health crisis that silently disables families and ends lives and livelihoods around the world. To date, however, no early biomarkers or effective therapies exist. It is now clear that brain microglia are more than mere bystanders or amyloid phagocytes; they can act as governors of neuronal function and homeostasis in the adult brain. Here, we highlight the fundamental role of microglia as tissueresident macrophages in neuronal health. Then, we suggest how chronic impairment in microglia-neuron crosstalk may secure the permanence of the failure of synaptic and neuronal function and health in Alzheimer's and Parkinson's diseases. Understanding how to assess and modulate microglia-neuron interactions critical for brain health will be key to developing effective therapies for dementia. © 2020, American Association for the Advancement of Science.
英文关键词	acyl coenzyme A desaturase; alpha synuclein; amyloid beta protein; apolipoprotein E; biological marker; complement component C1q; GBA1 protein; tau protein; triggering receptor expressed on myeloid cells 2; unclassified drug; alpha synuclein; amyloid; adult; cell; health impact; homeostasis; nervous system disorder; Alzheimer disease; ASAH1 gene; brain function; cell function; cell interaction; complement activation; CTSD gene; dementia; diffuse Lewy body disease; disease severity; GALC gene; GBA1 gene; genetic risk; gut brain axis; health; human; lipid metabolism; Lrrk2 gene; lysosome; macrophage; microglia; nerve cell; nerve degeneration; nonhuman; Parkinson disease; pathogenesis; priority journal; protein degradation; receptor cross-talk; Review; risk factor; Shy Drager syndrome; signal transduction; SLC17A5 gene; SMPD1 gene; SPTLC1 gene; synapse; synaptic loss; Alzheimer disease; animal; cell communication; metabolism; microglia; mouse; Parkinson disease; pathology; synaptosome; alpha-Synuclein; Alzheimer Disease; Amyloid; Animals; Cell Communication; Humans; Macrophages; Mice; Microglia; Neurons; Parkinson Disease; Synapses; Synaptosomes
语种	英语
来源期刊	Science
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/242968
作者单位	UK Dementia Research Institute, Institute of Neurology, University College London, London, WC1E 6BT, United Kingdom
推荐引用方式 GB/T 7714	Bartels T.,De Schepper S.,Hong S.. Microglia modulate neurodegeneration in Alzheimer's and Parkinson's diseases[J],2020,370(6512).
APA	Bartels T.,De Schepper S.,&Hong S..(2020).Microglia modulate neurodegeneration in Alzheimer's and Parkinson's diseases.Science,370(6512).
MLA	Bartels T.,et al."Microglia modulate neurodegeneration in Alzheimer's and Parkinson's diseases".Science 370.6512(2020).