气候变化领域集成服务门户(CCPortal): Somatic evolution and global expansion of an ancient transmissible cancer lineage

CCPortal

DOI	10.1126/science.aau9923
	Somatic evolution and global expansion of an ancient transmissible cancer lineage
	Baez-Ortega A.; Gori K.; Strakova A.; Allen J.L.; Allum K.M.; Bansse-Issa L.; Bhutia T.N.; Bisson J.L.; Briceño C.; Domracheva A.C.; Corrigan A.M.; Cran H.R.; Crawford J.T.; Davis E.; De Castro K.F.; De Nardi A.B.; De Vos A.P.; Keenan L.D.; Donelan E.M.; Espinoza Huerta A.R.; Faramade I.A.; Fazil M.; Fotopoulou E.; Fruean S.N.; Gallardo-Arrieta F.; Glebova O.; Gouletsou P.G.; Häfelin Manrique R.F.; Henriques J.J.G.P.; Horta R.S.; Ignatenko N.; Kane Y.; King C.; Koenig D.; Krupa A.; Kruzeniski S.J.; Kwon Y.-M.; Lanza-Perea M.; Lazyan M.; Lopez Quintana A.M.; Losfelt T.; Marino G.; Castañeda S.M.; Martínez-López M.F.; Meyer M.; Migneco E.J.; Nakanwagi B.; Neal K.B.; Neunzig W.; Leathlobhair M.N.; Nixon S.J.; Ortega-Pacheco A.; Pedraza-Ordoñez F.; Peleteiro M.C.; Polak K.; Pye R.J.; Reece J.F.; Gutierrez J.R.; Sadia H.; Schmeling S.K.; Shamanova O.; Sherlock A.G.; Stammnitz M.; Steenland-Smit A.E.; Svitich A.; Tapia Martínez L.J.; Ngoka I.T.; Torres C.G.; Tudor E.M.; Van Der Wel M.G.; Viţălaru B.A.; Vural S.A.; Walkinton O.; Wang J.; Wehrle-Martinez A.S.; Widdowson S.A.E.; Stratton M.R.; Alexandrov L.B.; Martincorena I.; Murchison E.P.
发表日期	2019
ISSN	0036-8075
卷号	365 期号:6452
英文摘要	The canine transmissible venereal tumor (CTVT) is a cancer lineage that arose several millennia ago and survives by “metastasizing” between hosts through cell transfer. The somatic mutations in this cancer record its phylogeography and evolutionary history. We constructed a time-resolved phylogeny from 546 CTVT exomes and describe the lineage's worldwide expansion. Examining variation in mutational exposure, we identify a highly context-specific mutational process that operated early in the cancer's evolution but subsequently vanished, correlate ultraviolet-light mutagenesis with tumor latitude, and describe tumors with heritable hyperactivity of an endogenous mutational process. CTVT displays little evidence of ongoing positive selection, and negative selection is detectable only in essential genes. We illustrate how long-lived clonal organisms capture changing mutagenic environments, and reveal that neutral genetic drift is the dominant feature of long-term cancer evolution. © 2019 American Association for the Advancement of Science. All rights reserved.
英文关键词	double stranded DNA; mitochondrial DNA; cancer; genetic drift; mutation; phylogeny; phylogeography; tumor; ultraviolet radiation; animal venereal tumor; Article; canine transmissible venereal tumor; disease transmission; DNA damage; gene expression; genetic drift; genetic variability; genomic instability; malignant neoplasm; mutational analysis; nonhuman; nonsense mutation; phylogenetic tree; phylogeography; priority journal; somatic mutation; ultraviolet radiation; whole exome sequencing; animal; animal venereal tumor; classification; clonal evolution; dog; dog disease; exosome; genetic selection; genetics; mutagenesis; phylogeny; Animals; Clonal Evolution; Dog Diseases; Dogs; Exosomes; Gene Expression; Mutagenesis; Phylogeny; Selection, Genetic; Venereal Tumors, Veterinary
语种	英语
来源期刊	Science
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/242925
作者单位	Transmissible Cancer Group, Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom; Animal Management in Rural and Remote Indigenous Communities (AMRRIC), Darwin, Australia; World Vets, Gig Harbor, United States; Animal Shelter, Stichting Dierenbescherming Suriname, Paramaribo, Suriname; Sikkim Anti-Rabies and Animal Health Programme, Department of Animal Husbandry, Livestock, Fisheries and Veterinary Services, Government of Sikkim, India; Royal (Dick) School of Veterinary Studies, Roslin Institute, University of Edinburgh, Easter Bush Campus, Roslin, EH25 9RG, United Kingdom; ConserLab, Animal Preventive Medicine Department, Faculty of Animal and Veterinary Sciences, University of Chile, Santiago, Chile; Corozal Veterinary Hospital, University of Panamá, Panama City, Panama; St. George's University, True Blue, Grenada; Nakuru District Veterinary Scheme Ltd, Nakuru, Kenya; Animal Medical Centre, Belize City, Belize; International Animal Welfare Training Institute, UC Davis S...
推荐引用方式 GB/T 7714	Baez-Ortega A.,Gori K.,Strakova A.,et al. Somatic evolution and global expansion of an ancient transmissible cancer lineage[J],2019,365(6452).
APA	Baez-Ortega A..,Gori K..,Strakova A..,Allen J.L..,Allum K.M..,...&Murchison E.P..(2019).Somatic evolution and global expansion of an ancient transmissible cancer lineage.Science,365(6452).
MLA	Baez-Ortega A.,et al."Somatic evolution and global expansion of an ancient transmissible cancer lineage".Science 365.6452(2019).