气候变化领域集成服务门户(CCPortal): Analysis of shared heritability in common disorders of the brain

CCPortal

DOI	10.1126/science.aap8757
	Analysis of shared heritability in common disorders of the brain
	Anttila V.; Bulik-Sullivan B.; Finucane H.K.; Walters R.K.; Bras J.; Duncan L.; Escott-Price V.; Falcone G.J.; Gormley P.; Malik R.; Patsopoulos N.A.; Ripke S.; Wei Z.; Yu D.; Lee P.H.; Turley P.; Grenier-Boley B.; Chouraki V.; Kamatani Y.; Berr C.; Letenneur L.; Hannequin D.; Amouyel P.; Boland A.; Deleuze J.-F.; Duron E.; Vardarajan B.N.; Reitz C.; Goate A.M.; Huentelman M.J.; Ilyas Kamboh M.; Larson E.B.; Rogaeva E.; George-Hyslop P.S.; Hakonarson H.; Kukull W.A.; Farrer L.A.; Barnes L.L.; Beach T.G.; Yesim Demirci F.; Head E.; Hulette C.M.; Jicha G.A.; Kauwe J.S.K.; Kaye J.A.; Leverenz J.B.; Levey A.I.; Lieberman A.P.; Pankratz V.S.; Poon W.W.; Quinn J.F.; Saykin A.J.; Schneider L.S.; Smith A.G.; Sonnen J.A.; Stern R.A.; Van Deerlin V.M.; Van Eldik L.J.; Harold D.; Russo G.; Rubinsztein D.C.; Bayer A.; Tsolaki M.; Proitsi P.; Fox N.C.; Hampel H.; Owen M.J.; Mead S.; Passmore P.; Morgan K.; Nöthen M.M.; Rossor M.; Lupton M.K.; Hoffmann P.; Kornhuber J.; Lawlor B.; McQuillin A.; Al-Chalabi A.; Bis J.C.; Ruiz A.; Boada M.; Seshadri S.; Beiser A.; Rice K.; Van Der Lee S.J.; De Jager P.L.; Geschwind D.H.; Riemenschneider M.; Riedel-Heller S.; Rotter J.I.; Ransmayr G.; Hyman B.T.; Cruchaga C.; Alegret M.; Winsvold B.; Palta P.; Farh K.-H.; Cuenca-Leon E.; Furlotte N.; Kurth T.; Ligthart L.; Terwindt G.M.; Freilinger T.; Ran C.; Gordon S.D.; Borck G.; Adams H.H.H.; Lehtimäki T.; Wedenoja J.; Buring J.E.; Schürks M.; Hrafnsdottir M.; Hottenga J.-J.; Penninx B.; Artto V.; Kaunisto M.; Vepsäläinen S.; Martin N.G.; Montgomery G.W.; Kurki M.I.; Hämäläinen E.; Huang H.; Huang J.; Sandor C.; Webber C.; Muller-Myhsok B.; Schreiber S.; Salomaa V.; Loehrer E.; Göbel H.; Macaya A.; Pozo-Rosich P.; Hansen T.; Werge T.; Kaprio J.; Metspalu A.; Kubisch C.; Ferrari M.D.; Belin A.C.; Van Den Maagdenberg A.M.J.M.; Zwart J.-A.; Boomsma D.; Eriksson N.; Olesen J.; Chasman D.I.; Nyholt D.R.; Avbersek A.; Baum L.; Berkovic S.; Bradfield J.; Buono R.; Catarino C.B.; Cossette P.; De Jonghe P.; Depondt C.; Dlugos D.; Ferraro T.N.; French J.; Hjalgrim H.; Jamnadas-Khoda J.; Kälviäinen R.; Kunz W.S.; Lerche H.; Leu C.; Lindhout D.; Lo W.; Lowenstein D.; McCormack M.; Møller R.S.; Molloy A.; Ng P.-W.; Oliver K.; Privitera M.; Radtke R.; Ruppert A.-K.; Sander T.; Schachter S.; Schankin C.; Scheffer I.; Schoch S.; Sisodiya S.M.; Smith P.; Sperling M.; Striano P.; Surges R.; Neil Thomas G.; Visscher F.; Whelan C.D.; Zara F.; Heinzen E.L.; Marson A.; Becker F.; Stroink H.; Zimprich F.; Gasser T.; Gibbs R.; Heutink P.; Martinez M.; Morris H.R.; Sharma M.; Ryten M.; Mok K.Y.; Pulit S.; Bevan S.; Holliday E.; Attia J.; Battey T.; Boncoraglio G.; Thijs V.; Chen W.-M.; Mitchell B.; Rothwell P.; Sharma P.; Sudlow C.; Vicente A.; Markus H.; Kourkoulis C.; Pera J.; Raffeld M.; Silliman S.; Perica V.B.; Thornton L.M.; Huckins L.M.; William Rayner N.; Lewis C.M.; Gratacos M.; Rybakowski F.; Keski-Rahkonen A.; Raevuori A.; Hudson J.I.; Reichborn-Kjennerud T.; Monteleone P.; Karwautz A.; Mannik K.; Baker J.H.; O'Toole J.K.; Trace S.E.; Davis O.S.P.; Helder S.G.; Ehrlich S.; Herpertz-Dahlmann B.; Danner U.N.; Van Elburg A.A.; Clementi M.; Forzan M.; Docampo E.; Lissowska J.; Hauser J.; Tortorella A.; Maj M.; Gonidakis F.; Tziouvas K.; Papezova H.; Yilmaz Z.; Wagner G.; Cohen-Woods S.; Herms S.; Julia A.; Rabionet R.; Dick D.M.; Ripatti S.; Andreassen O.A.; Espeseth T.; Lundervold A.J.; Steen V.M.; Pinto D.; Scherer S.W.; Aschauer H.; Schosser A.; Alfredsson L.; Padyukov L.; Halmi K.A.; Mitchell J.; Strober M.; Bergen A.W.; Kaye W.; Szatkiewicz J.P.; Cormand B.; Ramos-Quiroga J.A.; Sánchez-Mora C.; Ribasés M.; Casas M.; Hervas A.; Arranz M.J.; Haavik J.; Zayats T.; Johansson S.; Williams N.; Dempfle A.; Rothenberger A.; Kuntsi J.; Oades R.D.; Banaschewski T.; Franke B.; Buitelaar J.K.; Vasquez A.A.; Doyle A.E.; Reif A.; Lesch K.-P.; Freitag C.; Rivero O.; Palmason H.; Romanos M.; Langley K.; Rietschel M.; Witt S.H.; Dalsgaard S.; Børglum A.D.; Waldman I.; Wilmot B.; Molly N.; Bau C.H.D.; Crosbie J.; Schachar R.; Loo S.K.; McGough J.J.; Grevet E.H.; Medland S.E.; Robinson E.; Weiss L.A.; Bacchelli E.; Bailey A.; Bal V.; Battaglia A.; Betancur C.; Bolton P.; Cantor R.; Celestino-Soper P.; Dawson G.; De Rubeis S.; Duque F.; Green A.; Klauck S.M.; Leboyer M.; Levitt P.; Maestrini E.; Mane S.; Moreno-De-Luca D.; Parr J.; Regan R.; Reichenberg A.; Sandin S.; Vorstman J.; Wassink T.; Wijsman E.; Cook E.; Santangelo S.; Delorme R.; Roge B.; Magalhaes T.; Arking D.; Schulze T.G.; Thompson R.C.; Strohmaier J.; Matthews K.; Melle I.; Morris D.; Blackwood D.; McIntosh A.; Bergen S.E.; Schalling M.; Jamain S.; Maaser A.; Fischer S.B.; Reinbold C.S.; Fullerton J.M.; Guzman-Parra J.; Mayoral F.; Schofield P.R.; Cichon S.; Mühleisen T.W.; Degenhardt F.; Schumacher J.; Bauer M.; Mitchell P.B.; Gershon E.S.; Rice J.; Potash J.B.; Zandi P.P.; Craddock N.; Nicol Ferrier I.; Alda M.; Rouleau G.A.; Turecki G.; Ophoff R.; Pato C.; Anjorin A.; Stahl E.; Leber M.; Czerski P.M.; Cruceanu C.; Jones I.R.; Posthuma D.; Andlauer T.F.M.; Forstner A.J.; Streit F.; Baune B.T.; Air T.; Sinnamon G.; Wray N.R.; MacIntyre D.J.; Porteous D.; Homuth G.; Rivera M.; Grove J.; Middeldorp C.M.; Hickie I.; Pergadia M.; Mehta D.; Smit J.H.; Jansen R.; De Geus E.; Dunn E.; Li Q.S.; Nauck M.; Schoevers R.A.; Beekman A.T.F.; Knowles J.A.; Viktorin A.; Arnold P.; Barr C.L.; Bedoya-Berrio G.; Joseph Bienvenu O.; Brentani H.; Burton C.; Camarena B.; Cappi C.; Cath D.; Cavallini M.; Cusi D.; Darrow S.; Denys D.; Derks E.M.; Dietrich A.; Fernandez T.; Figee M.; Freimer N.; Gerber G.; Grados M.; Greenberg E.; Hanna G.L.; Hartmann A.; Hirschtritt M.E.; Hoekstra P.J.; Huang A.; Huyser C.; Illmann C.; Jenike M.; Kuperman S.; Leventhal B.; Lochner C.; Lyon G.J.; Macciardi F.; Madruga-Garrido M.; Malaty I.A.; Maras A.; McGrath L.; Miguel E.C.; Mir P.; Nestadt G.; Nicolini H.; Okun M.S.; Pakstis A.; Paschou P.; Piacentini J.; Pittenger C.; Plessen K.; Ramensky V.; Ramos E.M.; Reus V.; Richter M.A.; Riddle M.A.; Robertson M.M.; Roessner V.; Rosário M.; Samuels J.F.; Sandor P.; Stein D.J.; Tsetsos F.; Van Nieuwerburgh F.; Weatherall S.; Wendland J.R.; Wolanczyk T.; Worbe Y.; Zai G.; Goes F.S.; McLaughlin N.; Nestadt P.S.; Grabe H.-J.; Depienne C.; Konkashbaev A.; Lanzagorta N.; Valencia-Duarte A.; Bramon E.; Buccola N.; Cahn W.; Cairns M.; Chong S.A.; Cohen D.; Crespo-Facorro B.; Crowley J.; Davidson M.; DeLisi L.; Dinan T.; Donohoe G.; Drapeau E.; Duan J.; Haan L.; Hougaard D.; Karachanak-Yankova S.; Khrunin A.; Klovins J.; Kučinskas V.; Keong J.L.C.; Limborska S.; Loughland C.; Lönnqvist J.; Maher B.; Mattheisen M.; McDonald C.; Murphy K.C.; Nenadic I.; Van Os J.; Pantelis C.; Pato M.; Petryshen T.; Quested D.; Roussos P.; Sanders A.R.; Schall U.; Schwab S.G.; Sim K.; So H.-C.; Stögmann E.; Subramaniam M.; Toncheva D.; Waddington J.; Walters J.; Weiser M.; Cheng W.; Cloninger R.; Curtis D.; Gejman P.V.; Henskens F.; Mattingsdal M.; Oh S.-Y.; Scott R.; Webb B.; Breen G.; Churchhouse C.; Bulik C.M.; Daly M.; Dichgans M.; Faraone S.V.; Guerreiro R.; Holmans P.; Kendler K.S.; Koeleman B.; Mathews C.A.; Price A.; Scharf J.; Sklar P.; Williams J.; Wood N.W.; Cotsapas C.; Palotie A.; Smoller J.W.; Sullivan P.; Rosand J.; Corvin A.; Neale B.M.; The Brainstorm Consortium
发表日期	2018
ISSN	0036-8075
卷号	360 期号:6395
英文摘要	Disorders of the brain can exhibit considerable epidemiological comorbidity and often share symptoms, provoking debate about their etiologic overlap. We quantified the genetic sharing of 25 brain disorders from genome-wide association studies of 265,218 patients and 784,643 control participants and assessed their relationship to 17 phenotypes from 1,191,588 individuals. Psychiatric disorders share common variant risk, whereas neurological disorders appear more distinct from one another and from the psychiatric disorders. We also identified significant sharing between disorders and a number of brain phenotypes, including cognitive measures. Further, we conducted simulations to explore how statistical power, diagnostic misclassification, and phenotypic heterogeneity affect genetic correlations. These results highlight the importance of common genetic variation as a risk factor for brain disorders and the value of heritability-based methods in understanding their etiology. © 2018 American Association for the Advancement of Science. All rights reserved.
英文关键词	brain; disability; epidemiology; genetic analysis; genome; heritability; nervous system disorder; risk factor; symptom; Alzheimer disease; anorexia nervosa; Article; attention deficit disorder; bipolar disorder; brain ischemia; cognition; comorbidity; controlled study; educational status; genetic association; genetic risk; genetic variability; genome-wide association study; Gilles de la Tourette syndrome; heritability; human; major depression; mental disease; migraine; neurologic disease; neurosis; onset age; phenotype; priority journal; schizophrenia; brain disease; classification; genetic variation; genetics; mental disease; quantitative trait; risk factor; Brain Diseases; Genetic Variation; Genome-Wide Association Study; Humans; Mental Disorders; Phenotype; Quantitative Trait, Heritable; Risk Factors
语种	英语
来源期刊	Science
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/242880
作者单位	Analytic Translational Genetics Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States; Stanley Center for Psychiatric Research, Broad Institute of mit and Harvard, Cambridge, MA, United States; Program in Medical and Population Genetics, Broad Institute of mit and Harvard, Cambridge, MA, United States; Department of Mathematics, Massachusetts Institute of Technology, Cambridge, MA, United States; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, United States; UK Dementia Research Institute, University College London, London, United Kingdom; Department of Molecular Neuroscience, Institute of Neurology, University College London, London, United Kingdom; Department of Psychiatry and Behavioral Science, Stanford University, Stanford, CA, United States; Cardiff University, Medical Research Council Center for Neuropsychiatric Genetics and Genomics, Institute of Psychology, Medicine and Clinical Neuroscience, Cardiff, United Kingdom; Dementia Re...
推荐引用方式 GB/T 7714	Anttila V.,Bulik-Sullivan B.,Finucane H.K.,et al. Analysis of shared heritability in common disorders of the brain[J],2018,360(6395).
APA	Anttila V..,Bulik-Sullivan B..,Finucane H.K..,Walters R.K..,Bras J..,...&The Brainstorm Consortium.(2018).Analysis of shared heritability in common disorders of the brain.Science,360(6395).
MLA	Anttila V.,et al."Analysis of shared heritability in common disorders of the brain".Science 360.6395(2018).