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DOI	10.1126/science.aab1586
	Identification of the algal dimethyl sulfide-releasing enzyme: A missing link in the marine sulfur cycle
	Alcolombri U.; Ben-Dor S.; Feldmesser E.; Levin Y.; Tawfik D.S.; Vardi A.
发表日期	2015
ISSN	0036-8075
起始页码	1466
结束页码	1469
卷号	348 期号:6242
英文摘要	Algal blooms produce large amounts of dimethyl sulfide (DMS), a volatile with a diverse signaling role in marine food webs that is emitted to the atmosphere, where it can affect cloud formation. The algal enzymes responsible for forming DMS from dimethylsulfoniopropionate (DMSP) remain unidentified despite their critical role in the global sulfur cycle. We identified and characterized Alma1, a DMSP lyase from the bloom-forming algae Emiliania huxleyi. Alma1 is a tetrameric, redox-sensitive enzyme of the aspartate racemase superfamily. Recombinant Alma1 exhibits biochemical features identical to the DMSP lyase in E. huxleyi, and DMS released by various E. huxleyi isolates correlates with their Alma1 levels. Sequence homology searches suggest that Alma1 represents a gene family present in major, globally distributed phytoplankton taxa and in other marine organisms. © 2015, American Association for the Advancement of Science. All rights reserved.
英文关键词	Alma1 enzyme; aspartate racemase; dimethyl sulfide; dimethylsulfoniopropionate; lyase; unclassified drug; algal protein; dimethyl sulfide; dimethylsulfoniopropionate lyase; messenger RNA; recombinant protein; sulfide; algal bloom; dimethylsulfide; enzyme; food web; geographical distribution; marine ecosystem; phytoplankton; sulfur cycle; alga; algal bloom; Article; Emiliania huxleyi; Escherichia coli; genome; marine species; multigene family; nonhuman; phytoplankton; priority journal; proteomics; sequence homology; sulfur cycle; amino acid sequence; bacterium; biosynthesis; chemistry; classification; enzymology; genetics; Haptophyta; metabolism; molecular genetics; phylogeny; algae; Emiliania huxleyi; Algal Proteins; Amino Acid Sequence; Bacteria; Carbon-Sulfur Lyases; Haptophyta; Molecular Sequence Data; Phylogeny; Phytoplankton; Recombinant Proteins; RNA, Messenger; Sulfides
语种	英语
来源期刊	Science
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/242790
作者单位	Department of Biological Chemistry, Weizmann Institute of Science, Rehovot, 76100, Israel; Department of Plant and Environmental Sciences, Weizmann Institute of Science, Rehovot, 76100, Israel; Bioinformatics and Biological Computing Unit, Biological Services, Weizmann Institute of Science, Rehovot, 76100, Israel; Nancy and Stephen Grand Israel National Center for Personalized Medicine, Weizmann Institute of Science, Rehovot, 76100, Israel
推荐引用方式 GB/T 7714	Alcolombri U.,Ben-Dor S.,Feldmesser E.,et al. Identification of the algal dimethyl sulfide-releasing enzyme: A missing link in the marine sulfur cycle[J],2015,348(6242).
APA	Alcolombri U.,Ben-Dor S.,Feldmesser E.,Levin Y.,Tawfik D.S.,&Vardi A..(2015).Identification of the algal dimethyl sulfide-releasing enzyme: A missing link in the marine sulfur cycle.Science,348(6242).
MLA	Alcolombri U.,et al."Identification of the algal dimethyl sulfide-releasing enzyme: A missing link in the marine sulfur cycle".Science 348.6242(2015).