气候变化领域集成服务门户(CCPortal): Manipulating placebo analgesia and nocebo hyperalgesia by changing brain excitability

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DOI	10.1073/pnas.2101273118
	Manipulating placebo analgesia and nocebo hyperalgesia by changing brain excitability
	Tu Y.; Wilson G.; Camprodon J.; Dougherty D.D.; Vangel M.; Benedetti F.; Kaptchuk T.J.; Gollub R.L.; Kong J.
发表日期	2021
ISSN	0027-8424
卷号	118 期号:19
英文摘要	Harnessing placebo and nocebo effects has significant implications for research and medical practice. Placebo analgesia and nocebo hyperalgesia, the most well-studied placebo and nocebo effects, are thought to initiate from the dorsal lateral prefrontal cortex (DLPFC) and then trigger the brain's descending pain modulatory system and other pain regulation pathways. Combining repeated transcranial direct current stimulation (tDCS), an expectancy manipulation model, and functional MRI, we investigated the modulatory effects of anodal and cathodal tDCS at the right DLPFC on placebo analgesia and nocebo hyperalgesia using a randomized, double-blind and sham-controlled design. We found that compared with sham tDCS, active tDCS could 1) boost placebo and blunt nocebo effects and 2) modulate brain activity and connectivity associated with placebo analgesia and nocebo hyperalgesia. These results provide a basis for mechanistic manipulation of placebo and nocebo effects and may lead to improved clinical outcomes in medical practice. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	Dorsolateral prefrontal cortex; Expectancy manipulation; Mechanistic manipulation; Placebo and nocebo effects; Transcranial direct current stimulation
语种	英语
scopus关键词	capsaicin; lidocaine; adult; analgesia; Article; clinical outcome; controlled study; dorsolateral prefrontal cortex; electroencephalogram; female; functional connectivity; functional magnetic resonance imaging; human; human experiment; hyperalgesia; male; medical practice; nerve cell network; nocebo effect; nociception; normal human; placebo effect; priority journal; sensation; transcranial direct current stimulation
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/238925
作者单位	Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, United States; Department of Radiology, Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, United States; Department of Neuroscience, University of Turin Medical School, Turin, I-10126, Italy; Plateau Rosà Laboratories, Plateau Rosà, CH-3920, Switzerland; Program in Placebo Studies, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, United States
推荐引用方式 GB/T 7714	Tu Y.,Wilson G.,Camprodon J.,et al. Manipulating placebo analgesia and nocebo hyperalgesia by changing brain excitability[J],2021,118(19).
APA	Tu Y..,Wilson G..,Camprodon J..,Dougherty D.D..,Vangel M..,...&Kong J..(2021).Manipulating placebo analgesia and nocebo hyperalgesia by changing brain excitability.Proceedings of the National Academy of Sciences of the United States of America,118(19).
MLA	Tu Y.,et al."Manipulating placebo analgesia and nocebo hyperalgesia by changing brain excitability".Proceedings of the National Academy of Sciences of the United States of America 118.19(2021).