气候变化领域集成服务门户(CCPortal): Old vaccines for new infections: Exploiting innate immunity to control COVID-19 and prevent future pandemics

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DOI	10.1073/pnas.2101718118
	Old vaccines for new infections: Exploiting innate immunity to control COVID-19 and prevent future pandemics
	Chumakov K.; Avidan M.S.; Benn C.S.; Bertozzi S.M.; Blatt L.; Chang A.Y.; Jamison D.T.; Khader S.A.; Kottilil S.; Netea M.G.; Sparrow A.; Gallo R.C.
发表日期	2021
ISSN	0027-8424
卷号	118 期号:21
英文摘要	The COVID-19 pandemic triggered an unparalleled pursuit of vaccines to induce specific adaptive immunity, based on virus-neutralizing antibodies and T cell responses. Although several vaccines have been developed just a year after SARS-CoV-2 emerged in late 2019, global deployment will take months or even years. Meanwhile, the virus continues to take a severe toll on human life and exact substantial economic costs. Innate immunity is fundamental to mammalian host defense capacity to combat infections. Innate immune responses, triggered by a family of pattern recognition receptors, induce interferons and other cytokines and activate both myeloid and lymphoid immune cells to provide protection against a wide range of pathogens. Epidemiological and biological evidence suggests that the live-attenuated vaccines (LAV) targeting tuberculosis, measles, and polio induce protective innate immunity by a newly described form of immunological memory termed “trained immunity.” An LAV designed to induce adaptive immunity targeting a particular pathogen may also induce innate immunity that mitigates other infectious diseases, including COVID-19, as well as future pandemic threats. Deployment of existing LAVs early in pandemics could complement the development of specific vaccines, bridging the protection gap until specific vaccines arrive. The broad protection induced by LAVs would not be compromised by potential antigenic drift (immune escape) that can render viruses resistant to specific vaccines. LAVs might offer an essential tool to “bend the pandemic curve,” averting the exhaustion of public health resources and preventing needless deaths and may also have therapeutic benefits if used for postexposure prophylaxis of disease. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	Interferon; Nonspecific effects of live vaccines; SARS-CoV-2; Trained immunity
语种	英语
scopus关键词	BCG vaccine; chickenpox vaccine; interferon; live vaccine; measles mumps rubella vaccine; oral poliomyelitis vaccine; RNA vaccine; SARS-CoV-2 vaccine; live vaccine; vaccine; adaptive immunity; anaphylaxis; arthralgia; Article; coronavirus disease 2019; cost effectiveness analysis; drug efficacy; drug safety; epidemic; febrile convulsion; human; immune deficiency; innate immunity; medicine; nonhuman; pandemic; paralytic poliomyelitis; vaccination; heterologous immunity; immunological memory; immunology; pandemic; prevention and control; Adaptive Immunity; COVID-19; COVID-19 Vaccines; Immunity, Heterologous; Immunity, Innate; Immunologic Memory; Pandemics; SARS-CoV-2; Vaccines; Vaccines, Attenuated
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/238916
作者单位	Food and Drug Administration Office of Vaccine Research and Review, Global Virus Network Center of Excellence, Silver Spring, MD 20993, United States; Department of Anesthesiology, Washington University in St. Louis, St Louis, MO 63130, United States; Department of Clinical Research, Global Virus Network Center of Excellence, University of Southern Denmark, Odense, 5230, Denmark; Danish Institute for Advanced Study, University of Southern Denmark, Odense, 5230, Denmark; School of Public Health, Global Virus Network, University of California, Berkeley, CA 94704, United States; School of Public Health, University of Washington, Seattle, WA 98195, United States; El Centro de Investigación en Evaluación y Encuestas, Instituto Nacional de Salud Pública, Cuernavaca, 62100, Mexico; Aligos Therapeutics, Global Virus Network Center of Excellence, San Francisco, CA 94080, United States; Institute for Global Health Sciences, Global Virus Network, University of California, San Francisco, CA 94158, United States...
推荐引用方式 GB/T 7714	Chumakov K.,Avidan M.S.,Benn C.S.,et al. Old vaccines for new infections: Exploiting innate immunity to control COVID-19 and prevent future pandemics[J],2021,118(21).
APA	Chumakov K..,Avidan M.S..,Benn C.S..,Bertozzi S.M..,Blatt L..,...&Gallo R.C..(2021).Old vaccines for new infections: Exploiting innate immunity to control COVID-19 and prevent future pandemics.Proceedings of the National Academy of Sciences of the United States of America,118(21).
MLA	Chumakov K.,et al."Old vaccines for new infections: Exploiting innate immunity to control COVID-19 and prevent future pandemics".Proceedings of the National Academy of Sciences of the United States of America 118.21(2021).