气候变化领域集成服务门户(CCPortal): Violet light suppresses lens-induced myopia via neuropsin (OPN5) in mice

CCPortal

DOI	10.1073/pnas.2018840118
	Violet light suppresses lens-induced myopia via neuropsin (OPN5) in mice
	Jiang X.; Pardue M.T.; Mori K.; Ikeda S.-I.; Torii H.; D'Souza S.; Lang R.A.; Kurihara T.; Tsubota K.
发表日期	2021
ISSN	0027-8424
卷号	118 期号:22
英文摘要	Myopia has become a major public health concern, particularly across much of Asia. It has been shown in multiple studies that outdoor activity has a protective effect on myopia. Recent reports have shown that short-wavelength visible violet light is the component of sunlight that appears to play an important role in preventing myopia progression in mice, chicks, and humans. The mechanism underlying this effect has not been understood. Here, we show that violet light prevents lens defocus-induced myopia in mice. This violet light effect was dependent on both time of day and retinal expression of the violet light sensitive atypical opsin, neuropsin (OPN5). These findings identify Opn5-expressing retinal ganglion cells as crucial for emmetropization in mice and suggest a strategy for myopia prevention in humans. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	Myopia; Neuropsin (OPN5); Nonvisual photoreceptors; Violet light
语种	英语
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/238908
作者单位	Department of Ophthalmology, Keio University School of Medicine, Shinjuku-ku, Tokyo, 160-8582, Japan; Laboratory of Photobiology, Keio University School of Medicine, Shinjuku-ku, Tokyo, 160-8582, Japan; Center for Visual and Neurocognitive Rehabilitation, Atlanta Veterans Affairs Healthcare System, Atlanta, GA 30033, United States; Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA 30322, United States; Visual Systems Group, Abrahamson Pediatric Eye Institute, Division of Pediatric Ophthalmology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, United States; Department of Ophthalmology, College of Medicine, University of Cincinnati, Cincinnati, OH 45221, United States; Tsubota Laboratory, Inc., Tokyo, 160-0016, Japan
推荐引用方式 GB/T 7714	Jiang X.,Pardue M.T.,Mori K.,et al. Violet light suppresses lens-induced myopia via neuropsin (OPN5) in mice[J],2021,118(22).
APA	Jiang X..,Pardue M.T..,Mori K..,Ikeda S.-I..,Torii H..,...&Tsubota K..(2021).Violet light suppresses lens-induced myopia via neuropsin (OPN5) in mice.Proceedings of the National Academy of Sciences of the United States of America,118(22).
MLA	Jiang X.,et al."Violet light suppresses lens-induced myopia via neuropsin (OPN5) in mice".Proceedings of the National Academy of Sciences of the United States of America 118.22(2021).