气候变化领域集成服务门户(CCPortal): Chemotactic movement of a polarity site enables yeast cells to find their mates

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DOI	10.1073/pnas.2025445118
	Chemotactic movement of a polarity site enables yeast cells to find their mates
	Ghose D.; Jacobs K.; Ramirez S.; Elston T.; Lew D.
发表日期	2021
ISSN	0027-8424
卷号	118 期号:22
英文摘要	How small eukaryotic cells can interpret dynamic, noisy, and spatially complex chemical gradients to orient growth or movement is poorly understood. We address this question using Saccharomyces cerevisiae, where cells orient polarity up pheromone gradients during mating. Initial orientation is often incorrect, but polarity sites then move around the cortex in a search for partners. We find that this movement is biased by local pheromone gradients across the polarity site: that is, movement of the polarity site is chemotactic. A bottom-up computationalmodel recapitulates this biased movement. The model reveals how even though pheromone-bound receptors do not mimic the shape of external pheromone gradients, nonlinear and stochastic effects combine to generate effective gradient tracking. This mechanism for gradient tracking may be applicable to any cell that searches for a target in a complex chemical landscape. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	Cell polarity; Chemotropism; Modeling; Pheromone; Yeast
语种	英语
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/238901
作者单位	Computational Biology and Bioinformatics, Duke University, Durham, NC 27710, United States; Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, United States; Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, United States
推荐引用方式 GB/T 7714	Ghose D.,Jacobs K.,Ramirez S.,et al. Chemotactic movement of a polarity site enables yeast cells to find their mates[J],2021,118(22).
APA	Ghose D.,Jacobs K.,Ramirez S.,Elston T.,&Lew D..(2021).Chemotactic movement of a polarity site enables yeast cells to find their mates.Proceedings of the National Academy of Sciences of the United States of America,118(22).
MLA	Ghose D.,et al."Chemotactic movement of a polarity site enables yeast cells to find their mates".Proceedings of the National Academy of Sciences of the United States of America 118.22(2021).