气候变化领域集成服务门户(CCPortal): A catalog of tens of thousands of viruses from human metagenomes reveals hidden associations with chronic diseases

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DOI	10.1073/pnas.2023202118
	A catalog of tens of thousands of viruses from human metagenomes reveals hidden associations with chronic diseases
	Tisza M.J.; Buck C.B.
发表日期	2021
ISSN	0027-8424
卷号	118 期号:23
英文摘要	Despite remarkable strides in microbiome research, the viral component of the microbiome has generally presented a more challenging target than the bacteriome. This gap persists, even though many thousands of shotgun sequencing runs from human metagenomic samples exist in public databases, and all of them encompass large amounts of viral sequence data. The lack of a comprehensive database for human-associated viruses has historically stymied efforts to interrogate the impact of the virome on human health. This study probes thousands of datasets to uncover sequences from over 45,000 unique virus taxa, with historically high per-genome completeness. Large publicly available case-control studies are reanalyzed, and over 2,200 strong virus-disease associations are found. © This open access article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND).
英文关键词	Genomics; Microbiome; Virome
语种	英语
scopus关键词	Article; bacterial microbiome; bacteriophage; body regions; case control study; chronic disease; clustered regularly interspaced short palindromic repeat; controlled study; data analysis; disease association; GenBank; gene sequence; genetic association; genetic database; history; human; metagenome; nonhuman; taxonomy; virome; virus; virus assembly; virus cell interaction; virus classification; virus genome; virus identification; virus replication
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/238896
作者单位	Laboratory of Cellular Oncology, National Cancer Institute, NIH, Bethesda, MD 20892, United States
推荐引用方式 GB/T 7714	Tisza M.J.,Buck C.B.. A catalog of tens of thousands of viruses from human metagenomes reveals hidden associations with chronic diseases[J],2021,118(23).
APA	Tisza M.J.,&Buck C.B..(2021).A catalog of tens of thousands of viruses from human metagenomes reveals hidden associations with chronic diseases.Proceedings of the National Academy of Sciences of the United States of America,118(23).
MLA	Tisza M.J.,et al."A catalog of tens of thousands of viruses from human metagenomes reveals hidden associations with chronic diseases".Proceedings of the National Academy of Sciences of the United States of America 118.23(2021).