气候变化领域集成服务门户(CCPortal): Hypoimmune induced pluripotent stem cell–derived cell therapeutics treat cardiovascular and pulmonary diseases in immunocompetent allogeneic mice

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DOI	10.1073/pnas.2022091118
	Hypoimmune induced pluripotent stem cell–derived cell therapeutics treat cardiovascular and pulmonary diseases in immunocompetent allogeneic mice
	Deuse T.; Tediashvili G.; Hu X.; Gravina A.; Tamenang A.; Wang D.; Connolly A.; Mueller C.; Mallavia B.; Looney M.R.; Alawi M.; Lanier L.L.; Schrepfer S.
发表日期	2021
ISSN	0027-8424
卷号	118 期号:28
英文摘要	The emerging field of regenerative cell therapy is still limited by the few cell types that can reliably be differentiated from pluripotent stem cells and by the immune hurdle of commercially scalable allogeneic cell therapeutics. Here, we show that gene-edited, immune-evasive cell grafts can survive and successfully treat diseases in immunocompetent, fully allogeneic recipients. Transplanted endothelial cells improved perfusion and increased the likelihood of limb preservation in mice with critical limb ischemia. Endothelial cell grafts transduced to express a transgene for alpha1-antitrypsin (A1AT) successfully restored physiologic A1AT serum levels in mice with genetic A1AT deficiency. This cell therapy prevented both structural and functional changes of emphysematous lung disease. A mixture of endothelial cells and cardiomyocytes was injected into infarcted mouse hearts, and both cell types orthotopically engrafted in the ischemic areas. Cell therapy led to an improvement in invasive hemodynamic heart failure parameters. Our study supports the development of hypoimmune, universal regenerative cell therapeutics for cost-effective treatments of major diseases. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	Cell therapy; Hypoimmune stem cells; Immune evasion
语种	英语
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/238870
作者单位	Division of Cardiothoracic Surgery, Department of Surgery, Transplant and Stem Cell Immunobiology Laboratory, University of California, San Francisco, CA 94143, United States; Department of Cardiovascular Surgery, University Heart Center Hamburg, Hamburg, 20246, Germany; German Center for Cardiovascular Research (DZHK), partner site Hamburg/Kiel/Luebeck, Hamburg, 20246, Germany; Sana Biotechnology Inc., South San Francisco, CA 94080, United States; Department of Pathology, University of California, San Francisco, CA 94143, United States; Horae Gene Therapy Center, University of Massachusetts, Worcester, MA 01605, United States; Department of Pediatrics, University of Massachusetts, Worcester, MA 01605, United States; Department of Medicine, University of California, San Francisco, CA 94143, United States; Department of Laboratory Medicine, University of California, San Francisco, CA 94143, United States; Bioinformatics Core, University Medical Center Hamburg-Eppendorf, Hamburg, 20246, Germany; Depa...
推荐引用方式 GB/T 7714	Deuse T.,Tediashvili G.,Hu X.,等. Hypoimmune induced pluripotent stem cell–derived cell therapeutics treat cardiovascular and pulmonary diseases in immunocompetent allogeneic mice[J],2021,118(28).
APA	Deuse T..,Tediashvili G..,Hu X..,Gravina A..,Tamenang A..,...&Schrepfer S..(2021).Hypoimmune induced pluripotent stem cell–derived cell therapeutics treat cardiovascular and pulmonary diseases in immunocompetent allogeneic mice.Proceedings of the National Academy of Sciences of the United States of America,118(28).
MLA	Deuse T.,et al."Hypoimmune induced pluripotent stem cell–derived cell therapeutics treat cardiovascular and pulmonary diseases in immunocompetent allogeneic mice".Proceedings of the National Academy of Sciences of the United States of America 118.28(2021).