气候变化领域集成服务门户(CCPortal): Microbiome signatures of progression toward celiac disease onset in at-risk children in a longitudinal prospective cohort study

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DOI	10.1073/pnas.2020322118
	Microbiome signatures of progression toward celiac disease onset in at-risk children in a longitudinal prospective cohort study
	Leonard M.M.; Valitutti F.; Karathia H.; Pujolassos M.; Kenyon V.; Fanelli B.; Troisi J.; Subramanian P.; Camhi S.; Colucci A.; Serena G.; Cucchiara S.; Trovato C.M.; Malamisura B.; Francavilla R.; Elli L.; Hasan N.A.; Zomorrodi A.R.; Colwell R.; Fasano A.
发表日期	2021
ISSN	0027-8424
卷号	118 期号:29
英文摘要	Other than exposure to gluten and genetic compatibility, the gut microbiome has been suggested to be involved in celiac disease (CD) pathogenesis by mediating interactions between gluten/environmental factors and the host immune system. However, to establish disease progression markers, it is essential to assess alterations in the gut microbiota before disease onset. Here, a prospective metagenomic analysis of the gut microbiota of infants at risk of CD was done to track shifts in the microbiota before CD development. We performed cross-sectional and longitudinal analyses of gut microbiota, functional pathways, and metabolites, starting from 18 mo before CD onset, in 10 infants who developed CD and 10 matched nonaffected infants. Cross-sectional analysis at CD onset identified altered abundance of six microbial strains and several metabolites between cases and controls but no change in microbial species or pathway abundance. Conversely, results of longitudinal analysis revealed several microbial species/strains/pathways/metabolites occurring in increased abundance and detected before CD onset. These had previously been linked to autoimmune and inflammatory conditions (e.g., Dialister invisus, Parabacteroides sp., Lachnospiraceae, tryptophan metabolism, and metabolites serine and threonine). Others occurred in decreased abundance before CD onset and are known to have anti-inflammatory effects (e.g., Streptococcus thermophilus, Faecalibacterium prausnitzii, and Clostridium clostridioforme). Additionally, we uncovered previously unreported microbes/pathways/ metabolites (e.g., Porphyromonas sp., high mannose–type N-glycan biosynthesis, and serine) that point to CD-specific biomarkers. Our study establishes a road map for prospective longitudinal study designs to better understand the role of gut microbiota in disease pathogenesis and therapeutic targets to reestablish tolerance and/or prevent autoimmunity. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	Autoimmunity; Celiac disease; Gut microbiome; Multiomics analysis
语种	英语
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/238865
作者单位	Division of Pediatric Gastroenterology and Nutrition, MassGeneral Hospital for Children, Harvard Medical School, Boston, MA 02114, United States; Mucosal Immunology and Biology Research Center, MassGeneral Hospital for Children, Harvard Medical School, Boston, MA 02129, United States; Celiac Research Program, Harvard Medical School, Boston, MA 02114, United States; European Biomedical Research Institute of Salerno, Salerno, 84125, Italy; Pediatric Unit, Maternal and Child Health Department, Azienda Ospedaliera Universitaria San Giovanni di Dio e Ruggi d’Aragona, Salerno, 84125, Italy; CosmosID Inc., Rockville, MD 84100, United States; Theoreo srl, University of Salerno, Salerno, 20851, Italy; Department of Medicine, Surgery and Dentistry, Scuola Medica Salernitana, University of Salerno, Salerno, 84090, Italy; Pediatric Gastroenterology, Sapienza University of Rome, Rome, 84081, Italy; Pediatric Unit, Maternal and Child Health Department, Azienda Ospedaliera Universitaria San Giovanni di Dio e Ruggi d...
推荐引用方式 GB/T 7714	Leonard M.M.,Valitutti F.,Karathia H.,et al. Microbiome signatures of progression toward celiac disease onset in at-risk children in a longitudinal prospective cohort study[J],2021,118(29).
APA	Leonard M.M..,Valitutti F..,Karathia H..,Pujolassos M..,Kenyon V..,...&Fasano A..(2021).Microbiome signatures of progression toward celiac disease onset in at-risk children in a longitudinal prospective cohort study.Proceedings of the National Academy of Sciences of the United States of America,118(29).
MLA	Leonard M.M.,et al."Microbiome signatures of progression toward celiac disease onset in at-risk children in a longitudinal prospective cohort study".Proceedings of the National Academy of Sciences of the United States of America 118.29(2021).