气候变化领域集成服务门户(CCPortal): Nuclear envelope budding is a response to cellular stress

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DOI	10.1073/pnas.2020997118
	Nuclear envelope budding is a response to cellular stress
	Panagaki D.; Croft J.T.; Keuenhof K.; Berglund L.L.; Andersson S.; Kohler V.; Büttner S.; Tamás M.J.; Nyström T.; Neutze R.; Höög J.L.
发表日期	2021
ISSN	0027-8424
卷号	118 期号:30
英文摘要	Nuclear envelope budding (NEB) is a recently discovered alternative pathway for nucleocytoplasmic communication distinct from the movement of material through the nuclear pore complex. Through quantitative electron microscopy and tomography, we demonstrate how NEB is evolutionarily conserved from early protists to human cells. In the yeast Saccharomyces cerevisiae, NEB events occur with higher frequency during heat shock, upon exposure to arsenite or hydrogen peroxide, and when the proteasome is inhibited. Yeast cells treated with azetidine-2-carboxylic acid, a proline analog that induces protein misfolding, display the most dramatic increase in NEB, suggesting a causal link to protein quality control. This link was further supported by both localization of ubiquitin and Hsp104 to protein aggregates and NEB events, and the evolution of these structures during heat shock. We hypothesize that NEB is part of normal cellular physiology in a vast range of species and that in S. cerevisiae NEB comprises a stress response aiding the transport of protein aggregates across the nuclear envelope. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	Budding; Electron tomography; Nuclear transport; Protein quality control; Vesicles
语种	英语
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/238854
作者单位	Department of Chemistry and Molecular Biology, University of Gothenburg, Gothenburg, 405 30, Sweden; Department of Molecular Bioscienses, Wenner-Gren Institute, Stockholm University, Stockholm, 106 91, Sweden; Department of Microbiology and Immunology, University of Gothenburg, Gothenburg, 405 30, Sweden
推荐引用方式 GB/T 7714	Panagaki D.,Croft J.T.,Keuenhof K.,et al. Nuclear envelope budding is a response to cellular stress[J],2021,118(30).
APA	Panagaki D..,Croft J.T..,Keuenhof K..,Berglund L.L..,Andersson S..,...&Höög J.L..(2021).Nuclear envelope budding is a response to cellular stress.Proceedings of the National Academy of Sciences of the United States of America,118(30).
MLA	Panagaki D.,et al."Nuclear envelope budding is a response to cellular stress".Proceedings of the National Academy of Sciences of the United States of America 118.30(2021).