气候变化领域集成服务门户(CCPortal): Ventral pallidum regulates the default mode network, controlling transitions between internally and externally guided behavior

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DOI	10.1073/pnas.2103642118
	Ventral pallidum regulates the default mode network, controlling transitions between internally and externally guided behavior
	Klaassen A.-L.; Heiniger A.; Sánchez P.V.; Harvey M.A.; Rainer G.
发表日期	2021
ISSN	0027-8424
卷号	118 期号:36
英文摘要	Daily life requires transitions between performance of well-practiced, automatized behaviors reliant upon internalized representations and behaviors requiring external focus. Such transitions involve differential activation of the default mode network (DMN), a group of brain areas associated with inward focus. We asked how optogenetic modulation of the ventral pallidum (VP), a subcortical DMN node, impacts task switching between internally to externally guided lever-pressing behavior in the rat. Excitation of the VP dramatically compromised acquisition of an auditory discrimination task, trapping animals in a DMN state of automatized internally focused behavior and impairing their ability to direct attention to external sensory stimuli. VP inhibition, on the other hand, facilitated task acquisition, expediting escape from the DMN brain state, thereby allowing rats to incorporate the contingency changes associated with the auditory stimuli. We suggest that VP, instant by instant, regulates the DMN and plays a deterministic role in transitions between internally and externally guided behaviors. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	Anterior cingulate cortex; Basal forebrain; Default mode network; Operant behavior; Ventral pallidum
语种	英语
scopus关键词	animal experiment; anterior cingulate; article; attention; auditory discrimination; basal forebrain; default mode network; excitation; male; nonhuman; operant conditioning; rat; ventral pallidum
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/238814
作者单位	Department of Medicine, University of Fribourg, Fribourg, 1700, Switzerland; Department of Psychology, University of Fribourg, Fribourg, 1700, Switzerland
推荐引用方式 GB/T 7714	Klaassen A.-L.,Heiniger A.,Sánchez P.V.,et al. Ventral pallidum regulates the default mode network, controlling transitions between internally and externally guided behavior[J],2021,118(36).
APA	Klaassen A.-L.,Heiniger A.,Sánchez P.V.,Harvey M.A.,&Rainer G..(2021).Ventral pallidum regulates the default mode network, controlling transitions between internally and externally guided behavior.Proceedings of the National Academy of Sciences of the United States of America,118(36).
MLA	Klaassen A.-L.,et al."Ventral pallidum regulates the default mode network, controlling transitions between internally and externally guided behavior".Proceedings of the National Academy of Sciences of the United States of America 118.36(2021).