气候变化领域集成服务门户(CCPortal): Chronic toxoplasma gondii infection enhances susceptibility to colitis

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DOI	10.1073/pnas.2106730118
	Chronic toxoplasma gondii infection enhances susceptibility to colitis
	Saraav I.; Cervantes-Barragan L.; Olias P.; Fu Y.; Wang Q.; Wang L.; Wang Y.; Mack M.; Baldridge M.T.; Stappenbeck T.; Colonna M.; Sibley L.D.
发表日期	2021
ISSN	0027-8424
卷号	118 期号:36
英文摘要	Oral infection with Toxoplasma gondii results in dysbiosis and enteritis, both of which revert to normal during chronic infection. However, whether infection leaves a lasting impact on mucosal responses remains uncertain. Here we examined the effect of the chemical irritant dextran sodium sulfate (DSS) on intestinal damage and wound healing in chronically infected mice. Our findings indicate that prior infection with T. gondii exacerbates damage to the colon caused by DSS and impairs wound healing by suppressing stem cell regeneration of the epithelium. Enhanced tissue damage was attributable to inflammatory monocytes that emerge preactivated from bone marrow, migrate to the intestine, and release inflammatory mediators, including nitric oxide. Tissue damage was reversed by neutralization of inflammatory monocytes or nitric oxide, revealing a causal mechanism for tissue damage. Our findings suggest that chronic infection with T. gondii enhances monocyte activation to increase inflammation associated with a secondary environmental insult. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	Disbiosis; Inflammation; Monocytes; Nitric oxide; Toxoplasmosis
语种	英语
scopus关键词	dextran sulfate; nitric oxide; animal cell; animal experiment; animal model; animal tissue; Article; bone marrow; cell activation; cell migration; cell regeneration; chronic infection; colitis; colon injury; controlled study; disease exacerbation; enzyme repression; epithelium; female; infection risk; infection sensitivity; intestine injury; male; monocyte; mouse; nonhuman; stem cell; tissue injury; Toxoplasma gondii; toxoplasmosis; treatment outcome; upregulation; wound healing
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/238813
作者单位	Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, United States; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, United States; Department of Medicine, Division of Infectious Diseases, Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO 63110, United States; Department of Nephrology, University of Regensburg, Regensburg, 93042, Germany
推荐引用方式 GB/T 7714	Saraav I.,Cervantes-Barragan L.,Olias P.,et al. Chronic toxoplasma gondii infection enhances susceptibility to colitis[J],2021,118(36).
APA	Saraav I..,Cervantes-Barragan L..,Olias P..,Fu Y..,Wang Q..,...&Sibley L.D..(2021).Chronic toxoplasma gondii infection enhances susceptibility to colitis.Proceedings of the National Academy of Sciences of the United States of America,118(36).
MLA	Saraav I.,et al."Chronic toxoplasma gondii infection enhances susceptibility to colitis".Proceedings of the National Academy of Sciences of the United States of America 118.36(2021).