气候变化领域集成服务门户(CCPortal): High frequency of an otherwise rare phenotype in a small and isolated tiger population

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DOI	10.1073/pnas.2025273118
	High frequency of an otherwise rare phenotype in a small and isolated tiger population
	Sagar V.; Kaelin C.B.; Natesh M.; Reddy P.A.; Mohapatra R.K.; Chhattani H.; Thatte P.; Vaidyanathan S.; Biswas S.; Bhatt S.; Paul S.; Jhala Y.V.; Verma M.M.; Pandav B.; Mondol S.; Barsh G.S.; Swain D.; Ramakrishnan U.
发表日期	2021
ISSN	0027-8424
卷号	118 期号:39
英文摘要	Most endangered species exist today in small populations, many of which are isolated. Evolution in such populations is largely governed by genetic drift. Empirical evidence for drift affecting striking phenotypes based on substantial genetic data are rare. Approximately 37% of tigers (Panthera tigris) in the Similipal Tiger Reserve (in eastern India) are pseudomelanistic, characterized by wide, merged stripes. Camera trap data across the tiger range revealed the presence of pseudomelanistic tigers only in Similipal. We investigated the genetic basis for pseudomelanism and examined the role of drift in driving this phenotype's frequency. Whole-genome data and pedigree-based association analyses from captive tigers revealed that pseudomelanism cosegregates with a conserved and functionally important coding alteration in Transmembrane Aminopeptidase Q (Taqpep), a gene responsible for similar traits in other felid species. Noninvasive sampling of tigers revealed a high frequency of the Taqpep p.H454Y mutation in Similipal (12 individuals, allele frequency = 0.58) and absence from all other tiger populations (395 individuals). Population genetic analyses confirmed few (minimal number) tigers in Similipal, and its genetic isolation, with poor geneflow. Pairwise FST (0.33) at the mutation site was high but not an outlier. Similipal tigers had low diversity at 81 single nucleotide polymorphisms (mean heterozygosity = 0.28, SD = 0.27). Simulations were consistent with founding events and drift as possible drivers for the observed stark difference of allele frequency. Our results highlight the role of stochastic processes in the evolution of rare phenotypes.We highlight an unusual evolutionary trajectory in a small and isolated population of an endangered species. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	Drift; Genetics; Inbreeding; Pseudomelanism; Selection
语种	英语
scopus关键词	microsatellite DNA; amino acid sequence; animal; endangered species; environmental protection; evolution; genetic drift; genetic variation; genetics; genome; genotype; India; melanosis; phenotype; physiology; population genetics; sequence homology; tiger; Amino Acid Sequence; Animals; Biological Evolution; Conservation of Natural Resources; Endangered Species; Genetic Drift; Genetic Variation; Genetics, Population; Genome; Genotype; India; Melanosis; Microsatellite Repeats; Phenotype; Sequence Homology; Tigers
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/238793
作者单位	National Centre for Biological Sciences, Tata Institute of Fundamental Research, Bangalore, 560065, India; Department of Genetics, Stanford University, Palo Alto, CA 94309, United States; HudsonAlpha Institute for Biotechnology, Huntsville, AL 35806, United States; Biology Department, Indian Institute of Science Education and Research, Tirupati, 411008, India; Laboratory for Conservation of Endangered Species, Center for Cellular and Molecular Biology, Hyderabad, 500048, India; Nandankanan Biological Park, Bhubaneswar, 754005, India; World Wide Fund for Nature - India, New Delhi, 110003, India; Foundation for Ecological Research, Advocacy and Learning, Tamil Nadu, Auroville Post, 605101, India; Wildlife Institute of India, Dehradun, 248001, India; Odisha Forest Department, Bhubaneswar, 751023, India; National Tiger Conservation Authority, Wildlife Institute of India Tiger Cell, Wildlife Institute of India, Dehradun, 248001, India; State Forest Research Institute, Jabalpur, 482008, India; Former Member S...
推荐引用方式 GB/T 7714	Sagar V.,Kaelin C.B.,Natesh M.,et al. High frequency of an otherwise rare phenotype in a small and isolated tiger population[J],2021,118(39).
APA	Sagar V..,Kaelin C.B..,Natesh M..,Reddy P.A..,Mohapatra R.K..,...&Ramakrishnan U..(2021).High frequency of an otherwise rare phenotype in a small and isolated tiger population.Proceedings of the National Academy of Sciences of the United States of America,118(39).
MLA	Sagar V.,et al."High frequency of an otherwise rare phenotype in a small and isolated tiger population".Proceedings of the National Academy of Sciences of the United States of America 118.39(2021).