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DOI	10.1073/pnas.2109388118
	Robust and prototypical immune responses toward influenza vaccines in the high-risk group of Indigenous Australians
	Hensen L.; Nguyen T.H.O.; Rowntree L.C.; Damelang T.; Koutsakos M.; Aban M.; Hurt A.; Harland K.L.; Auladell M.; van de Sandt C.E.; Everitt A.; Blacker C.; Oyong D.A.; Loughland J.R.; Webb J.R.; Wines B.D.; Mark Hogarth P.; Flanagan K.L.; Plebanski M.; Wheatley A.; Chung A.W.; Kent S.J.; Miller A.; Bridie Clemens E.; Doherty P.C.; Nelson J.; Davies J.; Tong S.Y.C.; Kedzierska K.
发表日期	2021
ISSN	0027-8424
卷号	118 期号:41
英文摘要	Morbidity and mortality rates from seasonal and pandemic influenza occur disproportionately in high-risk groups, including Indigenous people globally. Although vaccination against influenza is recommended for those most at risk, studies on immune responses elicited by seasonal vaccines in Indigenous populations are largely missing, with no data available for Indigenous Australians and only one report published on antibody responses in Indigenous Canadians. We recruited 78 Indigenous and 84 non-Indigenous Australians vaccinated with the quadrivalent influenza vaccine into the Looking into InFluenza T cell immunity - Vaccination cohort study and collected blood to define baseline, early (day 7), and memory (day 28) immune responses. We performed in-depth analyses of T and B cell activation, formation of memory B cells, and antibody profiles and investigated host factors that could contribute to vaccine responses. We found activation profiles of circulating T follicular helper type-1 cells at the early stage correlated strongly with the total change in antibody titers induced by vaccination. Formation of influenza-specific hemagglutinin-binding memory B cells was significantly higher in seroconverters compared with nonseroconverters. In-depth antibody characterization revealed a reduction in immunoglobulin G3 before and after vaccination in the Indigenous Australian population, potentially linked to the increased frequency of the G3m21* allotype. Overall, our data provide evidence that Indigenous populations elicit robust, broad, and prototypical immune responses following immunization with seasonal inactivated influenza vaccines. Our work strongly supports the recommendation of influenza vaccination to protect Indigenous populations from severe seasonal influenza virus infections and their subsequent complications. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	Antibodies; B cells; Follicular T helper cells; Indigenous people; Influenza
语种	英语
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/238784
作者单位	Department of Microbiology and Immunology, University of Melbourne, The Peter Doherty Institute for Infection and Immunity, Parkville, VIC 3000, Australia; World Health Organization Collaborating Centre for Reference and Research on Influenza, The Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia; Department of Hematopoiesis, Sanquin Research and Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam, Amsterdam, 1066 CX, Netherlands; Menzies School of Health Research, Charles Darwin University, Darwin, NT 0810, Australia; Center for Global Infectious Disease Research (CGIDR), Seattle Children’s Research Institute, Seattle, WA 98109, United States; Immunology Group, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4029, Australia; Immune Therapies Laboratory, Burnet Institute, Melbourne, VIC 3084, Australia; Department of Immunology and Pathology, Central Clinical School, Monash University, Melbourne, VIC 3010, Australia; Department of Clinical Pathol...
推荐引用方式 GB/T 7714	Hensen L.,Nguyen T.H.O.,Rowntree L.C.,et al. Robust and prototypical immune responses toward influenza vaccines in the high-risk group of Indigenous Australians[J],2021,118(41).
APA	Hensen L..,Nguyen T.H.O..,Rowntree L.C..,Damelang T..,Koutsakos M..,...&Kedzierska K..(2021).Robust and prototypical immune responses toward influenza vaccines in the high-risk group of Indigenous Australians.Proceedings of the National Academy of Sciences of the United States of America,118(41).
MLA	Hensen L.,et al."Robust and prototypical immune responses toward influenza vaccines in the high-risk group of Indigenous Australians".Proceedings of the National Academy of Sciences of the United States of America 118.41(2021).