气候变化领域集成服务门户(CCPortal): Short-term high-fat feeding exacerbates degeneration in retinitis pigmentosa by promoting retinal oxidative stress and inflammation

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DOI	10.1073/pnas.2100566118
	Short-term high-fat feeding exacerbates degeneration in retinitis pigmentosa by promoting retinal oxidative stress and inflammation
	Kutsyr O.; Noailles A.; Martínez-Gil N.; Maestre-Carballa L.; Martinez-Garcia M.; Maneu V.; Cuenca N.; Lax P.
发表日期	2021
ISSN	0027-8424
卷号	118 期号:43
英文摘要	A high-fat diet (HFD) can induce hyperglycemia and metabolic syndromes that, in turn, can trigger visual impairment. To evaluate the acute effects of HFD feeding on retinal degeneration, we assessed retinal function and morphology, inflammatory state, oxidative stress, and gut microbiome in dystrophic retinal degeneration 10 (rd10) mice, a model of retinitis pigmentosa, fed an HFD for 2 to 3 wk. Short-term HFD feeding impaired retinal responsiveness and visual acuity and enhanced photoreceptor degeneration, microglial cell activation, and Muller € cell gliosis. HFD consumption also triggered the expression of inflammatory and oxidative markers in rd10 retinas. Finally, an HFD caused gut microbiome dysbiosis, increasing the abundance of potentially proinflammatory bacteria. Thus, HFD feeding drives the pathological processes of retinal degeneration by promoting oxidative stress and activating inflammatory-related pathways. Our findings suggest that consumption of an HFD could accelerate the progression of the disease in patients with retinal degenerative disorders. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	Cell death; Gut microbiome; Neurodegeneration; Retinal degeneration
语种	英语
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/238771
作者单位	Department of Physiology, Genetics and Microbiology, University of Alicante, Alicante, 03690, Spain; Department of Optics, Pharmacology and Anatomy, University of Alicante, Alicante, 03690, Spain; Institute Ramón Margalef, University of Alicante, Alicante, 03690, Spain
推荐引用方式 GB/T 7714	Kutsyr O.,Noailles A.,Martínez-Gil N.,et al. Short-term high-fat feeding exacerbates degeneration in retinitis pigmentosa by promoting retinal oxidative stress and inflammation[J],2021,118(43).
APA	Kutsyr O..,Noailles A..,Martínez-Gil N..,Maestre-Carballa L..,Martinez-Garcia M..,...&Lax P..(2021).Short-term high-fat feeding exacerbates degeneration in retinitis pigmentosa by promoting retinal oxidative stress and inflammation.Proceedings of the National Academy of Sciences of the United States of America,118(43).
MLA	Kutsyr O.,et al."Short-term high-fat feeding exacerbates degeneration in retinitis pigmentosa by promoting retinal oxidative stress and inflammation".Proceedings of the National Academy of Sciences of the United States of America 118.43(2021).