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| DOI | 10.1073/pnas.2004833118 |
| Synthetic threads through the web of life | |
| Power M.E. | |
| 发表日期 | 2021 |
| ISSN | 0027-8424 |
| 卷号 | 118期号:22 |
| 英文摘要 | CRISPR-Cas gene editing tools have brought us to an era of synthetic biology that will change the world. Excitement over the breakthroughs these tools have enabled in biology and medicine is balanced, justifiably, by concern over how their applications might go wrong in open environments. We do not know how genomic processes (including regulatory and epigenetic processes), evolutionary change, ecosystem interactions, and other higher order processes will affect traits, fitness, and impacts of edited organisms in nature. However, anticipating the spread, change, and impacts of edited traits or organisms in heterogeneous, changing environments is particularly important with "gene drives on the horizon." To anticipate how "synthetic threads" will affect the web of life on Earth, scientists must confront complex system interactions across many levels of biological organization. Currently, we lack plans, infrastructure, and funding for field science and scientists to track new synthetic organisms, with or without gene drives, as they move through open environments. © 2021 National Academy of Sciences. All rights reserved. |
| 英文关键词 | CRISPR; Ecological impacts; Gene drives; Interaction strength; Scale linkages |
| 语种 | 英语 |
| scopus关键词 | article; clustered regularly interspaced short palindromic repeat; funding |
| 来源期刊 | Proceedings of the National Academy of Sciences of the United States of America
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| 文献类型 | 期刊论文 |
| 条目标识符 | http://gcip.llas.ac.cn/handle/2XKMVOVA/238723 |
| 作者单位 | Department of Integrative Biology, University of California, Berkeley, CA 94720, United States |
| 推荐引用方式 GB/T 7714 | Power M.E.. Synthetic threads through the web of life[J],2021,118(22). |
| APA | Power M.E..(2021).Synthetic threads through the web of life.Proceedings of the National Academy of Sciences of the United States of America,118(22). |
| MLA | Power M.E.."Synthetic threads through the web of life".Proceedings of the National Academy of Sciences of the United States of America 118.22(2021). |
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