气候变化领域集成服务门户(CCPortal): Genealogical structure changes as range expansions transition from pushed to pulled

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DOI	10.1073/pnas.2026746118
	Genealogical structure changes as range expansions transition from pushed to pulled
	Birzu G.; Hallatschek O.; Korolev K.S.
发表日期	2021
ISSN	0027-8424
卷号	118 期号:34
英文摘要	Range expansions accelerate evolution through multiple mechanisms, including gene surfing and genetic drift. The inference and control of these evolutionary processes ultimately rely on the information contained in genealogical trees. Currently, there are two opposing views on how range expansions shape genealogies. In invasion biology, expansions are typically approximated by a series of population bottlenecks producing genealogies with only pairwise mergers between lineages—a process known as the Kingman coalescent. Conversely, traveling wave models predict a coalescent with multiple mergers, known as the Bolthausen–Sznitman coalescent. Here, we unify these two approaches and show that expansions can generate an entire spectrum of coalescent topologies. Specifically, we show that tree topology is controlled by growth dynamics at the front and exhibits large differences between pulled and pushed expansions. These differences are explained by the fluctuations in the total number of descendants left by the early founders. High growth cooperativity leads to a narrow distribution of reproductive values and the Kingman coalescent. Conversely, low growth cooperativity results in a broad distribution, whose exponent controls the merger sizes in the genealogies. These broad distribution and non-Kingman tree topologies emerge due to the fluctuations in the front shape and position and do not occur in quasi-deterministic simulations. Overall, our results show that range expansions provide a robust mechanism for generating different types of multiple mergers, which could be similar to those observed in populations with strong selection or high fecundity. Thus, caution should be exercised in making inferences about the origin of non-Kingman genealogies. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	Coalescent; Neutral genetic diversity; Offspring distribution; Range expansion; Traveling wave
语种	英语
scopus关键词	article; controlled study; fertility; genealogy; genetic variability; progeny; simulation; travel
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/238659
作者单位	Department of Physics, Boston University, Boston, MA 02215, United States; Department of Applied Physics, Stanford University, Stanford, CA 94305, United States; Department of Physics, University of California, Berkeley, CA 94720, United States; Department of Integrative Biology, University of California, Berkeley, CA 94720, United States; Department of Physics, Boston University, Boston, MA 02215, United States; Graduate Program in Bioinformatics, Boston University, Boston, MA 02215, United States
推荐引用方式 GB/T 7714	Birzu G.,Hallatschek O.,Korolev K.S.. Genealogical structure changes as range expansions transition from pushed to pulled[J],2021,118(34).
APA	Birzu G.,Hallatschek O.,&Korolev K.S..(2021).Genealogical structure changes as range expansions transition from pushed to pulled.Proceedings of the National Academy of Sciences of the United States of America,118(34).
MLA	Birzu G.,et al."Genealogical structure changes as range expansions transition from pushed to pulled".Proceedings of the National Academy of Sciences of the United States of America 118.34(2021).