气候变化领域集成服务门户(CCPortal): Koala retrovirus genetic diversity and transmission dynamics within captive koala populations

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DOI	10.1073/pnas.2024021118
	Koala retrovirus genetic diversity and transmission dynamics within captive koala populations
	Joyce B.A.; Blyton M.D.J.; Johnston S.D.; Young P.R.; Chappell K.J.
发表日期	2021
ISSN	0027-8424
卷号	118 期号:38
英文摘要	Koala populations are currently in rapid decline across Australia, with infectious diseases being a contributing cause. The koala retrovirus (KoRV) is a gammaretrovirus present in both captive and wild koala colonies that presents an additional challenge for koala conservation in addition to habitat loss, climate change, and other factors. Currently, nine different subtypes (A to I) have been identified; however, KoRV genetic diversity analyses have been limited. KoRV is thought to be exogenously transmitted between individuals, with KoRV-A also being endogenous and transmitted through the germline. The mechanisms of exogenous KoRV transmission are yet to be extensively investigated. Here, deep sequencing was employed on 109 captive koalas of known pedigree, housed in two institutions from Southeast Queensland, to provide a detailed analysis of KoRV transmission dynamics and genetic diversity. The final dataset included 421 unique KoRV sequences, along with the finding of an additional subtype (KoRV-K). Our analysis suggests that exogenous transmission of KoRV occurs primarily between dam and joey, with evidence provided for multiple subtypes, including nonendogenized KoRV-A. No evidence of sexual transmission was observed, with mating partners found to share a similar number of sequences as unrelated koala pairs. Importantly, both distinct captive colonies showed similar trends. These findings indicate that breeding strategies or antiretroviral treatment of females could be employed as effective management approaches in combating KoRV transmission. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	Diversity; Evolution; Koala; Retrovirus; Transmission
语种	英语
scopus关键词	Article; evolution; female; genetic variability; koala; Koala retrovirus; male; microbial diversity; nonhuman; pedigree; sequence analysis; virus transmission
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/238641
作者单位	School of Chemistry and Molecular Biosciences, University of Queensland, St. Lucia, QLD 4072, Australia; School of Agriculture and Food Sciences, University of Queensland, Gatton, QLD 4343, Australia; Australian Institute for Bioengineering and Nanotechnology, University of Queensland, St. Lucia, QLD 4072, Australia
推荐引用方式 GB/T 7714	Joyce B.A.,Blyton M.D.J.,Johnston S.D.,et al. Koala retrovirus genetic diversity and transmission dynamics within captive koala populations[J],2021,118(38).
APA	Joyce B.A.,Blyton M.D.J.,Johnston S.D.,Young P.R.,&Chappell K.J..(2021).Koala retrovirus genetic diversity and transmission dynamics within captive koala populations.Proceedings of the National Academy of Sciences of the United States of America,118(38).
MLA	Joyce B.A.,et al."Koala retrovirus genetic diversity and transmission dynamics within captive koala populations".Proceedings of the National Academy of Sciences of the United States of America 118.38(2021).