气候变化领域集成服务门户(CCPortal): A revised action spectrum for vitamin D synthesis by suberythemal UV radiation exposure in humans in vivo

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DOI	10.1073/pnas.2015867118
	A revised action spectrum for vitamin D synthesis by suberythemal UV radiation exposure in humans in vivo
	Young A.R.; Morgan K.A.; Harrison G.I.; Lawrence K.P.; Petersen B.; Wulf H.C.; Philipsen P.A.
发表日期	2021
ISSN	0027-8424
卷号	118 期号:40
英文摘要	Action spectra are important biological weighting functions for risk/ benefit analyses of ultraviolet (UV) radiation (UVR) exposure. One important human benefit of exposure to terrestrial solar UVB radiation (∼295 to 315 nm) is the cutaneous synthesis of vitamin D3 that is initiated by the photoconversion of 7-dehydrocholesterol to previtamin D3. An action spectrum for this process that is followed by other nonphotochemical steps to achieve biologically active vitamin D3 has been established from ex vivo data and is widely used, although its validity has been questioned. We tested this action spectrum in vivo by full- or partial-body suberythemal irradiation of 75 healthy young volunteers with five different polychromatic UVR spectra on five serial occasions. Serum 25-hydroxyvitamin D3 [25(OH) D3] levels, as the most accurate measure of vitamin D3 status, were assessed before, during, and after the exposures. These were then used to generate linear dose–response curves that were different for each UVR spectrum. It was established that the previtamin D3 action spectrum was not valid when related to the serum 25(OH)D3 levels, as weighting the UVR doses with this action spectrum did not result in a common regression line unless it was adjusted by a blue shift, with 5 nm giving the best fit. Such a blue shift is in accord with the published in vitro action spectra for vitamin D3 synthesis. Thus, calculations regarding the risk (typically erythema) versus the benefit of exposure to solar UVR based on the ex vivo previtamin D3 action spectrum require revision. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	Action spectum; Human skin; UVR; Vitamin D
语种	英语
scopus关键词	calcifediol; adult; Article; biosynthesis; erythema; human; human experiment; in vivo study; normal human; radiation dose; radiation exposure; skin; solar radiation; sun exposure; ultraviolet radiation; vitamin blood level
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/238628
作者单位	St. John’s Institute of Dermatology, School of Basic and Biomedical Sciences, Faculty of Life Sciences and Medicine, King’s College London, London, SE1 9RT, United Kingdom; Global Medical Affairs, LEO Pharma, Ballerup, 2750, Denmark; Department of Dermatology D92, Copenhagen University Hospital - Bispebjerg, Copenhagen, DK-2400, Denmark
推荐引用方式 GB/T 7714	Young A.R.,Morgan K.A.,Harrison G.I.,et al. A revised action spectrum for vitamin D synthesis by suberythemal UV radiation exposure in humans in vivo[J],2021,118(40).
APA	Young A.R..,Morgan K.A..,Harrison G.I..,Lawrence K.P..,Petersen B..,...&Philipsen P.A..(2021).A revised action spectrum for vitamin D synthesis by suberythemal UV radiation exposure in humans in vivo.Proceedings of the National Academy of Sciences of the United States of America,118(40).
MLA	Young A.R.,et al."A revised action spectrum for vitamin D synthesis by suberythemal UV radiation exposure in humans in vivo".Proceedings of the National Academy of Sciences of the United States of America 118.40(2021).