气候变化领域集成服务门户(CCPortal): Ecological diversification reveals routes of pathogen emergence in endemic Vibrio vulnificus populations

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DOI	10.1073/pnas.2103470118
	Ecological diversification reveals routes of pathogen emergence in endemic Vibrio vulnificus populations
	López-Pérez M.; Jayakumar J.M.; Grant T.-A.; Zaragoza-Solas A.; Cabello-Yeves P.J.; Almagro-Moreno S.
发表日期	2021
ISSN	0027-8424
卷号	118 期号:40
英文摘要	Pathogen emergence is a complex phenomenon that, despite its public health relevance, remains poorly understood. Vibrio vulnificus, an emergent human pathogen, can cause a deadly septicaemia with over 50% mortality rate. To date, the ecological drivers that lead to the emergence of clinical strains and the unique genetic traits that allow these clones to colonize the human host remain mostly unknown. We recently surveyed a large estuary in eastern Florida, where outbreaks of the disease frequently occur, and found endemic populations of the bacterium. We established two sampling sites and observed strong correlations between location and pathogenic potential. One site is significantly enriched with strains that belong to one phylogenomic cluster (C1) in which the majority of clinical strains belong. Interestingly, strains isolated from this site exhibit phenotypic traits associated with clinical outcomes, whereas strains from the second site belong to a cluster that rarely causes disease in humans (C2). Analyses of C1 genomes indicate unique genetic markers in the form of clinical-associated alleles with a potential role in virulence. Finally, metagenomic and physicochemical analyses of the sampling sites indicate that this marked cluster distribution and genetic traits are strongly associated with distinct biotic and abiotic factors (e.g., salinity, nutrients, or biodiversity), revealing how ecosystems generate selective pressures that facilitate the emergence of specific strains with pathogenic potential in a population. This knowledge can be applied to assess the risk of pathogen emergence from environmental sources and integrated toward the development of novel strategies for the prevention of future outbreaks. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	Aquatic pathogens; Pathogen emergence; Population genomics; Vibrio vulnificus; Virulence evolution
语种	英语
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/238625
作者单位	Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, FL 32816, United States; National Center for Integrated Coastal Research, University of Central Florida, Orlando, FL 32816, United States; Evolutionary Genomics Group, División de Microbiología, Universidad Miguel Hernández, Alicante, 03550, Spain
推荐引用方式 GB/T 7714	López-Pérez M.,Jayakumar J.M.,Grant T.-A.,et al. Ecological diversification reveals routes of pathogen emergence in endemic Vibrio vulnificus populations[J],2021,118(40).
APA	López-Pérez M.,Jayakumar J.M.,Grant T.-A.,Zaragoza-Solas A.,Cabello-Yeves P.J.,&Almagro-Moreno S..(2021).Ecological diversification reveals routes of pathogen emergence in endemic Vibrio vulnificus populations.Proceedings of the National Academy of Sciences of the United States of America,118(40).
MLA	López-Pérez M.,et al."Ecological diversification reveals routes of pathogen emergence in endemic Vibrio vulnificus populations".Proceedings of the National Academy of Sciences of the United States of America 118.40(2021).