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DOI	10.1073/pnas.2110711118
	Spillover, hybridization, and persistence in schistosome transmission dynamics at the human–animal interface
	Borlase A.; Rudge J.W.; Léger E.; Diouf N.D.; Fall C.B.; Diop S.D.; Catalano S.; Sène M.; Webster J.P.
发表日期	2021
ISSN	0027-8424
卷号	118 期号:41
英文摘要	Zoonotic spillover and hybridization of parasites are major emerging public and veterinary health concerns at the interface of infectious disease biology, evolution, and control. Schistosomiasis is a neglected tropical disease of global importance caused by parasites of the Schistosoma genus, and the Schistosoma spp. system within Africa represents a key example of a system where spillover of animal parasites into human populations has enabled formation of hybrids. Combining model-based approaches and analyses of parasitological, molecular, and epidemiological data from northern Senegal, a region with a high prevalence of schistosome hybrids, we aimed to unravel the transmission dynamics of this complex multihost, multiparasite system. Using Bayesian methods and by estimating the basic reproduction number (R0), we evaluate the frequency of zoonotic spillover of Schistosoma bovis from livestock and the potential for onward transmission of hybrid S. bovis × S. haematobium offspring within human populations. We estimate R0 of hybrid schistosomes to be greater than the critical threshold of one (1.76; 95% CI 1.59 to 1.99), demonstrating the potential for hybridization to facilitate spread and establishment of schistosomiasis beyond its original geographical boundaries. We estimate R0 for S. bovis to be greater than one in cattle (1.43; 95% CI 1.24 to 1.85) but not in other ruminants, confirming cattle as the primary zoonotic reservoir. Through longitudinal simulations, we also show that where S. bovis and S. haematobium are coendemic (in livestock and humans respectively), the relative importance of zoonotic transmission is predicted to increase as the disease in humans nears elimination. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	Hybrids; Modelling; R0; Schistosomiasis; Spillover
语种	英语
scopus关键词	praziquantel; Article; basic reproduction number; goat; hybridization; mass drug administration; mathematical model; miracidium; nucleotide sequence; parasite transmission; protozoan zoonosis; ruminant; Schistosoma; Schistosoma bovis; Schistosoma curassoni; Schistosoma haematobium; schistosomiasis; Senegal; sheep; simulation; worm burden; zoonotic spillover
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/238619
作者单位	Centre for Emerging, Endemic and Exotic Diseases, Department of Pathobiology and Population Sciences, Royal Veterinary College, University of London, Hatfield, AL9 7TA, United Kingdom; Communicable Diseases Policy Research Group, Department of Global Health and Development, London School of Hygiene and Tropical Medicine, London, WC1E 7HT, United Kingdom; Faculty of Public Health, Mahidol University, Nakhon Pathom, 73170, Thailand; Institut Supérieur de Formation Agricole et Rurale, Université de Thiès, BP 54, Bambey, Senegal; Unité de Formation et de Recherche des Sciences Agronomiques, d’Aquaculture et de Technologies Alimentaires, Université Gaston Berger, BP 32000, Saint-Louis, Senegal; Service de Parasitologie – Mycologie, Faculté de Médecine, Pharmacie et Odontologie, Université Cheikh Anta Diop, Dakar, BP 5005, Senegal
推荐引用方式 GB/T 7714	Borlase A.,Rudge J.W.,Léger E.,等. Spillover, hybridization, and persistence in schistosome transmission dynamics at the human–animal interface[J],2021,118(41).
APA	Borlase A..,Rudge J.W..,Léger E..,Diouf N.D..,Fall C.B..,...&Webster J.P..(2021).Spillover, hybridization, and persistence in schistosome transmission dynamics at the human–animal interface.Proceedings of the National Academy of Sciences of the United States of America,118(41).
MLA	Borlase A.,et al."Spillover, hybridization, and persistence in schistosome transmission dynamics at the human–animal interface".Proceedings of the National Academy of Sciences of the United States of America 118.41(2021).