气候变化领域集成服务门户(CCPortal): Spatial variation in the joint effect of extreme heat events and ozone on respiratory hospitalizations in California

CCPortal

DOI	10.1073/pnas.2023078118
	Spatial variation in the joint effect of extreme heat events and ozone on respiratory hospitalizations in California
	Schwarz L.; Hansen K.; Alari A.; Ilango S.D.; Bernal N.; Basu R.; Gershunov A.; Benmarhnia T.
发表日期	2021
ISSN	0027-8424
卷号	118 期号:22
英文摘要	Extreme heat and ozone are co-occurring exposures that independently and synergistically increase the risk of respiratory disease. To our knowledge, no joint warning systems consider both risks; understanding their interactive effect can warrant use of comprehensive warning systems to reduce their burden. We examined heterogeneity in joint effects (on the additive scale) between heat and ozone at small geographical scales. A within-community matched design with a Bayesian hierarchical model was applied to study this association at the zip code level. Spatially varying relative risks due to interaction (RERI) were quantified to consider joint effects. Determinants of the spatial variability of effects were assessed using a random effects metaregression to consider the role of demographic/neighborhood characteristics that are known effect modifiers. A total of 817,354 unscheduled respiratory hospitalizations occurred in California from 2004 to 2013 in the May to September period. RERIs revealed no additive interaction when considering overall joint effects. However, when considering the zip code level, certain areas observed strong joint effects. A lower median income, higher percentage of unemployed residents, and exposure to other air pollutants within a zip code drove stronger joint effects; a higher percentage of commuters who walk/bicycle, a marker for neighborhood wealth, showed decreased effects. Results indicate the importance of going beyond average measures to consider spatial variation in the health burden of these exposures and predictors of joint effects. This information can be used to inform early warning systems that consider both heat and ozone to protect populations from these deleterious effects in identified areas. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	Extreme heat; Health; Joint effects; Ozone; Spatial analysis
语种	英语
scopus关键词	ozone; air pollutant; Article; California; correlational study; environmental exposure; environmental temperature; extreme hot weather; hospitalization; human; income; respiratory tract disease; risk factor; trend study; unemployment
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/238545
作者单位	School of Public Health, San Diego State University, San Diego, CA 92182, United States; Herbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego, San diego, CA 92093, United States; Sorbonne Université, INSERM, Institut Pierre Louis d'Épidémiologie et de Santé Publique, NEMESIS Research Team, Paris, F75012, France; Department of Epidemiology, University of Washington, Seattle, WA 98195, United States; Center for Sustainable Development, University of Brasilia, Brasilia, 70910-900, Brazil; Office of Environmental Health Hazard Assessment, California Environmental Protection Agency, Oakland, CA 94612, United States; Scripps Institution of Oceanography, University of California San Diego, San diego, CA 92038, United States
推荐引用方式 GB/T 7714	Schwarz L.,Hansen K.,Alari A.,et al. Spatial variation in the joint effect of extreme heat events and ozone on respiratory hospitalizations in California[J],2021,118(22).
APA	Schwarz L..,Hansen K..,Alari A..,Ilango S.D..,Bernal N..,...&Benmarhnia T..(2021).Spatial variation in the joint effect of extreme heat events and ozone on respiratory hospitalizations in California.Proceedings of the National Academy of Sciences of the United States of America,118(22).
MLA	Schwarz L.,et al."Spatial variation in the joint effect of extreme heat events and ozone on respiratory hospitalizations in California".Proceedings of the National Academy of Sciences of the United States of America 118.22(2021).