气候变化领域集成服务门户(CCPortal): Epigenetic inheritance of DNA methylation changes in fish living in hydrogen sulfide-rich springs

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DOI	10.1073/pnas.2014929118
	Epigenetic inheritance of DNA methylation changes in fish living in hydrogen sulfide-rich springs
	Kelley J.L.; Tobler M.; Beck D.; Sadler-Riggleman I.; Quackenbush C.R.; Rodriguez L.A.; Skinner M.K.
发表日期	2021
ISSN	0027-8424
卷号	118 期号:26
英文摘要	Environmental factors can promote phenotypic variation through alterations in the epigenome and facilitate adaptation of an organism to the environment. Although hydrogen sulfide is toxic to most organisms, the fish Poecilia mexicana has adapted to survive in environments with high levels that exceed toxicity thresholds by orders of magnitude. Epigenetic changes in response to this environmental stressor were examined by assessing DNA methylation alterations in red blood cells, which are nucleated in fish. Males and females were sampled from sulfidic and nonsulfidic natural environments; individuals were also propagated for two generations in a nonsulfidic laboratory environment. We compared epimutations between the sexes as well as field and laboratory populations. For both the wild-caught (F0) and the laboratory-reared (F2) fish, comparing the sulfidic and nonsulfidic populations revealed evidence for significant differential DNA methylation regions (DMRs). More importantly, there was over 80% overlap in DMRs across generations, suggesting that the DMRs have stable generational inheritance in the absence of the sulfidic environment. This is an example of epigenetic generational stability after the removal of an environmental stressor. The DMR-associated genes were related to sulfur toxicity and metabolic processes. These findings suggest that adaptation of P. mexicana to sulfidic environments in southern Mexico may, in part, be promoted through epigenetic DNA methylation alterations that become stable and are inherited by subsequent generations independent of the environment. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	Adaptation; Epigenetic; Inheritance; Sulfidic environment
语种	英语
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/238506
作者单位	School of Biological Sciences, Washington State University, Pullman, WA 99163, United States; Division of Biology, Kansas State University, Manhattan, KS 66506, United States; División Académica de Ciencias Biológicas, Universidad Juárez Autónoma de Tabasco, Villahermosa, 86150, Mexico; Center for Reproductive Biology, Washington State University, Pullman, WA 99163, United States
推荐引用方式 GB/T 7714	Kelley J.L.,Tobler M.,Beck D.,et al. Epigenetic inheritance of DNA methylation changes in fish living in hydrogen sulfide-rich springs[J],2021,118(26).
APA	Kelley J.L..,Tobler M..,Beck D..,Sadler-Riggleman I..,Quackenbush C.R..,...&Skinner M.K..(2021).Epigenetic inheritance of DNA methylation changes in fish living in hydrogen sulfide-rich springs.Proceedings of the National Academy of Sciences of the United States of America,118(26).
MLA	Kelley J.L.,et al."Epigenetic inheritance of DNA methylation changes in fish living in hydrogen sulfide-rich springs".Proceedings of the National Academy of Sciences of the United States of America 118.26(2021).