气候变化领域集成服务门户(CCPortal): Clock proteins and training modify exercise capacity in a daytime-dependent manner

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DOI	10.1073/pnas.2101115118
	Clock proteins and training modify exercise capacity in a daytime-dependent manner
	Adamovich Y.; Dandavate V.; Ezagouri S.; Manella G.; Zwighaft Z.; Sobel J.; Kuperman Y.; Golik M.; Auerbach A.; Itkin M.; Malitsky S.; Asher G.
发表日期	2021
ISSN	0027-8424
卷号	118 期号:35
英文摘要	Exercise and circadian biology are closely intertwined with physiology and metabolism, yet the functional interaction between circadian clocks and exercise capacity is only partially characterized. Here, we tested different clock mutant mouse models to examine the effect of the circadian clock and clock proteins, namely PERIODs and BMAL1, on exercise capacity. We found that daytime variance in endurance exercise capacity is circadian clock controlled. Unlike wild-type mice, which outperform in the late compared with the early part of their active phase, PERIODs- and BMAL1-null mice do not show daytime variance in exercise capacity. It appears that BMAL1 impairs and PERIODs enhance exercise capacity in a daytime-dependent manner. An analysis of liver and muscle glycogen stores as well as muscle lipid utilization suggested that these daytime effects mostly relate to liver glycogen levels and correspond to the animals' feeding behavior. Furthermore, given that exercise capacity responds to training, we tested the effect of training at different times of the day and found that training in the late compared with the early part of the active phase improves exercise performance. Overall, our findings suggest that clock proteins shape exercise capacity in a daytime-dependent manner through changes in liver glycogen levels, likely due to their effect on animals' feeding behavior. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	Circadian clocks; Exercise; Glycogen; Metabolism; Training
语种	英语
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/238414
作者单位	Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, 7610001, Israel; Department of Veterinary Resources, Weizmann Institute of Science, Rehovot, 7610001, Israel; Department of Chemical Research Support, Weizmann Institute of Science, Rehovot, 7610001, Israel; Department of Life Sciences Core Facilities, Weizmann Institute of Science, Rehovot, 7610001, Israel
推荐引用方式 GB/T 7714	Adamovich Y.,Dandavate V.,Ezagouri S.,et al. Clock proteins and training modify exercise capacity in a daytime-dependent manner[J],2021,118(35).
APA	Adamovich Y..,Dandavate V..,Ezagouri S..,Manella G..,Zwighaft Z..,...&Asher G..(2021).Clock proteins and training modify exercise capacity in a daytime-dependent manner.Proceedings of the National Academy of Sciences of the United States of America,118(35).
MLA	Adamovich Y.,et al."Clock proteins and training modify exercise capacity in a daytime-dependent manner".Proceedings of the National Academy of Sciences of the United States of America 118.35(2021).