气候变化领域集成服务门户(CCPortal): Metabolism modulates network synchrony in the aging brain

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DOI	10.1073/pnas.2025727118
	Metabolism modulates network synchrony in the aging brain
	Weistuch C.; Mujica-Parodi L.R.; Razban R.M.; Antal B.; van Nieuwenhuizen H.; Amgalan A.; Dill K.A.
发表日期	2021
ISSN	0027-8424
卷号	118 期号:40
英文摘要	Brain aging is associated with hypometabolism and global changes in functional connectivity. Using functional MRI (fMRI), we show that network synchrony, a collective property of brain activity, decreases with age. Applying quantitative methods from statistical physics, we provide a generative (Ising) model for these changes as a function of the average communication strength between brain regions. We find that older brains are closer to a critical point of this communication strength, in which even small changes in metabolism lead to abrupt changes in network synchrony. Finally, by experimentally modulating metabolic activity in younger adults, we show how metabolism alone—independent of other changes associated with aging—can provide a plausible candidate mechanism for marked reorganization of brain network topology. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	Aging; Criticality; FMRI; Neurometabolism; Synchrony
语种	英语
scopus关键词	adult; aging; article; brain region; controlled study; functional magnetic resonance imaging; nerve cell network; physics; quantitative analysis; functional magnetic resonance imaging
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/238349
作者单位	Laufer Center for Physical and Quantitative Biology, Stony Brook University, Stony Brook, NY 11794, United States; Department of Applied Mathematics and Statistics, Stony Brook University, Stony Brook, NY 11794, United States; Department of Biomedical Engineering, Stony Brook University, Stony Brook, NY 11794, United States; Program in Neuroscience, Stony Brook University, Stony Brook, NY 11794, United States; Department of Physics and Astronomy, Stony Brook University, Stony Brook, NY 11794, United States; Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, United States; Department of Chemistry, Stony Brook University, Stony Brook, NY 11794, United States
推荐引用方式 GB/T 7714	Weistuch C.,Mujica-Parodi L.R.,Razban R.M.,et al. Metabolism modulates network synchrony in the aging brain[J],2021,118(40).
APA	Weistuch C..,Mujica-Parodi L.R..,Razban R.M..,Antal B..,van Nieuwenhuizen H..,...&Dill K.A..(2021).Metabolism modulates network synchrony in the aging brain.Proceedings of the National Academy of Sciences of the United States of America,118(40).
MLA	Weistuch C.,et al."Metabolism modulates network synchrony in the aging brain".Proceedings of the National Academy of Sciences of the United States of America 118.40(2021).