气候变化领域集成服务门户(CCPortal): Ultrasensitive multispecies spectroscopic breath analysis for real-time health monitoring and diagnostics

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DOI	10.1073/pnas.2105063118
	Ultrasensitive multispecies spectroscopic breath analysis for real-time health monitoring and diagnostics
	Liang Q.; Chan Y.-C.; Bryan Changala P.; Nesbitt D.J.; Ye J.; Toscano J.
发表日期	2021
ISSN	0027-8424
卷号	118 期号:40
英文摘要	Breath analysis enables rapid, noninvasive diagnostics, as well as long-term monitoring of human health, through the identification and quantification of exhaled biomarkers. Here, we demonstrate the remarkable capabilities of mid-infrared (mid-IR) cavity-enhanced direct-frequency comb spectroscopy (CE-DFCS) applied to breath analysis. We simultaneously detect and monitor as a function of time four breath biomarkers—CH3OH, CH4, H2O, and HDO—as well as illustrate the feasibility of detecting at least six more (H2CO, C2H6, OCS, C2H4, CS2, and NH3) without modifications to the experimental apparatus. We achieve ultrahigh detection sensitivity at the parts-per-trillion level. This is made possible by the combination of the broadband spectral coverage of a frequency comb, the high spectral resolution afforded by the individual comb teeth, and the sensitivity enhancement resulting from a high-finesse cavity. Exploiting recent advances in frequency comb, optical coating, and photodetector technologies, we can access a large variety of biomarkers with strong carbon–hydrogen-bond spectral signatures in the mid-IR. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	Breath analysis; Frequency combs; Spectroscopy
语种	英语
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/238348
作者单位	JILA, National Institute of Standards and Technology, University of Colorado Boulder, Boulder, CO 80309, United States; Department of Physics, University of Colorado Boulder, Boulder, CO 80309, United States; Department of Chemistry, University of Colorado Boulder, Boulder, CO 80309, United States; Center for Astrophysics, Harvard College Observatory, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, United States
推荐引用方式 GB/T 7714	Liang Q.,Chan Y.-C.,Bryan Changala P.,et al. Ultrasensitive multispecies spectroscopic breath analysis for real-time health monitoring and diagnostics[J],2021,118(40).
APA	Liang Q.,Chan Y.-C.,Bryan Changala P.,Nesbitt D.J.,Ye J.,&Toscano J..(2021).Ultrasensitive multispecies spectroscopic breath analysis for real-time health monitoring and diagnostics.Proceedings of the National Academy of Sciences of the United States of America,118(40).
MLA	Liang Q.,et al."Ultrasensitive multispecies spectroscopic breath analysis for real-time health monitoring and diagnostics".Proceedings of the National Academy of Sciences of the United States of America 118.40(2021).