气候变化领域集成服务门户(CCPortal): Dietary ω-3 polyunsaturated fatty acids are protective for myopia

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DOI	10.1073/pnas.2104689118
	Dietary ω-3 polyunsaturated fatty acids are protective for myopia
	Pan M.; Zhao F.; Xie B.; Wu H.; Zhang S.; Ye C.; Guan Z.; Kang L.; Zhang Y.; Zhou X.; Lei Y.; Wang Q.; Wang L.; Yang F.; Zhao C.; Qu J.; Zhou X.
发表日期	2021
ISSN	0027-8424
卷号	118 期号:43
英文摘要	Myopia is a leading cause of visual impairment and blindness worldwide. However, a safe and accessible approach for myopia control and prevention is currently unavailable. Here, we investigated the therapeutic effect of dietary supplements of omega-3 polyunsaturated fatty acids (ω-3 PUFAs) on myopia progression in animal models and on decreases in choroidal blood perfusion (ChBP) caused by near work, a risk factor for myopia in young adults. We demonstrated that daily gavage of ω-3 PUFAs (300 mg docosahexaenoic acid [DHA] plus 60 mg eicosapentaenoic acid [EPA]) significantly attenuated the development of form deprivation myopia in guinea pigs and mice, as well as of lens-induced myopia in guinea pigs. Peribulbar injections of DHA also inhibited myopia progression in form-deprived guinea pigs. The suppression of myopia in guinea pigs was accompanied by inhibition of the “ChBP reduction–scleral hypoxia cascade.” Additionally, treatment with DHA or EPA antagonized hypoxia-induced myofibroblast transdifferentiation in cultured human scleral fibroblasts. In human subjects, oral administration of ω-3 PUFAs partially alleviated the near-work–induced decreases in ChBP. Therefore, evidence from these animal and human studies suggests ω-3 PUFAs are potential and readily available candidates for myopia control. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	Choroidal blood perfusion; Myofibroblast; Myopia; Scleral hypoxia; Transdifferentiation; ω-3 PUFAs
语种	英语
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/238325
作者单位	School of Ophthalmology and Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou, 325027, China; State Key Laboratory of Optometry, Ophthalmology, and Vision Science, Wenzhou, 325027, China; National Clinical Research Center for Ocular Diseases, Wenzhou, 325027, China; Oujiang Laboratory, Zhejiang Lab for Regenerative Medicine, Vision and Brain Health, Wenzhou, 325001, China; Research Unit of Myopia Basic Research and Clinical Prevention and Control, Chinese Academy of Medical Sciences, Wenzhou, 325027, China
推荐引用方式 GB/T 7714	Pan M.,Zhao F.,Xie B.,et al. Dietary ω-3 polyunsaturated fatty acids are protective for myopia[J],2021,118(43).
APA	Pan M..,Zhao F..,Xie B..,Wu H..,Zhang S..,...&Zhou X..(2021).Dietary ω-3 polyunsaturated fatty acids are protective for myopia.Proceedings of the National Academy of Sciences of the United States of America,118(43).
MLA	Pan M.,et al."Dietary ω-3 polyunsaturated fatty acids are protective for myopia".Proceedings of the National Academy of Sciences of the United States of America 118.43(2021).