气候变化领域集成服务门户(CCPortal): Serum apolipoprotein A-I depletion is causative to silica nanoparticles-induced cardiovascular damage

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DOI	10.1073/pnas.2108131118
	Serum apolipoprotein A-I depletion is causative to silica nanoparticles-induced cardiovascular damage
	Liu X.; Wei W.; Liu Z.; Song E.; Lou J.; Feng L.; Huang R.; Chen C.; Ke P.C.; Song Y.
发表日期	2021
ISSN	0027-8424
卷号	118 期号:44
英文摘要	The rapid development of nanotechnology has greatly benefited modern science and engineering and also led to an increased environmental exposure to nanoparticles (NPs). While recent research has established a correlation between the exposure of NPs and cardiovascular diseases, the intrinsic mechanisms of such a connection remain unclear. Inhaled NPs can penetrate the air-blood barrier from the lung to systemic circulation, thereby intruding the cardiovascular system and generating cardiotoxic effects. In this study, on-site cardiovascular damage was observed in mice upon respiratory exposure of silica nanoparticles (SiNPs), and the corresponding mechanism was investigated by focusing on the interaction of SiNPs and their encountered biomacromolecules en route. SiNPs were found to collect a significant amount of apolipoprotein A-I (Apo A-I) from the blood, in particular when the SiNPs were preadsorbed with pulmonary surfactants. While the adsorbed Apo A-I ameliorated the cytotoxic and proinflammatory effects of SiNPs, the protein was eliminated from the blood upon clearance of the NPs. However, supplementation of Apo A-I mimic peptide mitigated the atherosclerotic lesion induced by SiNPs. In addition, we found a further declined plasma Apo A-I level in clinical silicosis patients than coronary heart disease patients, suggesting clearance of SiNPs sequestered Apo A-I to compromise the coronal protein's regular biological functions. Together, this study has provided evidence that the protein corona of SiNPs acquired in the blood depletes Apo A-I, a biomarker for prediction of cardiovascular diseases, which gives rise to unexpected toxic effects of the nanoparticles. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	Apolipoprotein A-I; Atherosclerosis; Cardiovascular damage; Corona; Silica nanoparticle
语种	英语
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/238321
作者单位	Key Laboratory of Luminescence Analysis and Molecular Sensing, Ministry of Education, College of Pharmaceutical Sciences, Southwest University, Chongqing, 400715, China; State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, 100085, China; School of Public Health, Hangzhou Medical College, Hangzhou, 310051, China; Department of Cardiology, Beijing Friendship Hospital, Capital Medical University, Beijing, 100053, China; Chinese Academy of Sciences Center for Excellence in Nanoscience, Chinese Academy of Sciences Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology of China, Beijing, 100190, China; Research Unit of Nanoscience and Technology, Chinese Academy of Medical Sciences, Beijing, 100039, China; Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD 4072, Australia; Nanomedicine Center, The ...
推荐引用方式 GB/T 7714	Liu X.,Wei W.,Liu Z.,et al. Serum apolipoprotein A-I depletion is causative to silica nanoparticles-induced cardiovascular damage[J],2021,118(44).
APA	Liu X..,Wei W..,Liu Z..,Song E..,Lou J..,...&Song Y..(2021).Serum apolipoprotein A-I depletion is causative to silica nanoparticles-induced cardiovascular damage.Proceedings of the National Academy of Sciences of the United States of America,118(44).
MLA	Liu X.,et al."Serum apolipoprotein A-I depletion is causative to silica nanoparticles-induced cardiovascular damage".Proceedings of the National Academy of Sciences of the United States of America 118.44(2021).