气候变化领域集成服务门户(CCPortal): Bacterial marginolactones trigger formation of algal gloeocapsoids, protective aggregates on the verge of multicellularity

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DOI	10.1073/pnas.2100892118
	Bacterial marginolactones trigger formation of algal gloeocapsoids, protective aggregates on the verge of multicellularity
	Krespach M.K.C.; Stroe M.C.; Flak M.; Komor A.J.; Nietzsche S.; Sasso S.; Hertweck C.; Brakhage A.A.
发表日期	2021
ISSN	0027-8424
卷号	118 期号:45
英文摘要	Photosynthetic microorganisms including the green alga Chlamydomonas reinhardtii are essential to terrestrial habitats as they start the carbon cycle by conversion of CO2 to energy-rich organic carbohydrates. Terrestrial habitats are densely populated, and hence, microbial interactions mediated by natural products are inevitable. We previously discovered such an interaction between Streptomyces iranensis releasing the marginolactone azalomycin F in the presence of C. reinhardtii. Whether the alga senses and reacts to azalomycin F remained unknown. Here, we report that sublethal concentrations of azalomycin F trigger the formation of a protective multicellular structure by C. reinhardtii, which we named gloeocapsoid. Gloeocapsoids contain several cells which share multiple cell membranes and cell walls and are surrounded by a spacious matrix consisting of acidic polysaccharides. After azalomycin F removal, gloeocapsoid aggregates readily disassemble, and single cells are released. The presence of marginolactone biosynthesis gene clusters in numerous streptomycetes, their ubiquity in soil, and our observation that other marginolactones such as desertomycin A andmonazomycin also trigger the formation of gloeocapsoids suggests a cross-kingdom competition with ecological relevance. Furthermore, gloeocapsoids allow for the survival of C. reinhardtii at alkaline pH and otherwise lethal concentrations of azalomycin F. Their structure and polysaccharide matrix may be ancestral to the complex mucilage formed by multicellular members of the Chlamydomonadales such as Eudorina and Volvox. Our finding suggests that multicellularity may have evolved to endure the presence of harmful competing bacteria. Additionally, it underlines the importance of natural products as microbial cues, which initiate interesting ecological scenarios of attack and counter defense. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	Evolution; Microbial interaction; Morphology; Multicellularity; Natural products
语种	英语
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/238312
作者单位	Department of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology, Jena, 07745, Germany; Institute of Microbiology, Friedrich Schiller University Jena, Jena, 07745, Germany; Department of Biomolecular Chemistry, Leibniz Institute for Natural Product Research and Infection Biology, Jena, 07745, Germany; Electron Microscopy Center, University Hospital Jena, Jena, 07743, Germany; Department of Plant Physiology, Institute of Biology, Leipzig University, Leipzig, 04103, Germany
推荐引用方式 GB/T 7714	Krespach M.K.C.,Stroe M.C.,Flak M.,et al. Bacterial marginolactones trigger formation of algal gloeocapsoids, protective aggregates on the verge of multicellularity[J],2021,118(45).
APA	Krespach M.K.C..,Stroe M.C..,Flak M..,Komor A.J..,Nietzsche S..,...&Brakhage A.A..(2021).Bacterial marginolactones trigger formation of algal gloeocapsoids, protective aggregates on the verge of multicellularity.Proceedings of the National Academy of Sciences of the United States of America,118(45).
MLA	Krespach M.K.C.,et al."Bacterial marginolactones trigger formation of algal gloeocapsoids, protective aggregates on the verge of multicellularity".Proceedings of the National Academy of Sciences of the United States of America 118.45(2021).