气候变化领域集成服务门户(CCPortal): Single-cell atlas of domestic pig cerebral cortex and hypothalamus

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DOI	10.1016/j.scib.2021.04.002
	Single-cell atlas of domestic pig cerebral cortex and hypothalamus
	Zhu J.; Chen F.; Luo L.; Wu W.; Dai J.; Zhong J.; Lin X.; Chai C.; Ding P.; Liang L.; Wang S.; Ding X.; Chen Y.; Wang H.; Qiu J.; Wang F.; Sun C.; Zeng Y.; Fang J.; Jiang X.; Liu P.; Tang G.; Qiu X.; Zhang X.; Ruan Y.; Jiang S.; Li J.; Zhu S.; Xu X.; Li F.; Liu Z.; Cao G.; Chen D.
发表日期	2021
ISSN	20959273
起始页码	1448
结束页码	1461
卷号	66 期号:14
英文摘要	The brain of the domestic pig (Sus scrofa domesticus) has drawn considerable attention due to its high similarities to that of humans. However, the cellular compositions of the pig brain (PB) remain elusive. Here we investigated the single-nucleus transcriptomic profiles of five regions of the PB (frontal lobe, parietal lobe, temporal lobe, occipital lobe, and hypothalamus) and identified 21 cell subpopulations. The cross-species comparison of mouse and pig hypothalamus revealed the shared and specific gene expression patterns at the single-cell resolution. Furthermore, we identified cell types and molecular pathways closely associated with neurological disorders, bridging the gap between gene mutations and pathogenesis. We reported, to our knowledge, the first single-cell atlas of domestic pig cerebral cortex and hypothalamus combined with a comprehensive analysis across species, providing extensive resources for future research regarding neural science, evolutionary developmental biology, and regenerative medicine. © 2021 Science China Press
关键词	Brain cell atlas Domestic pig Neural science Single-cell transcriptome
英文关键词	Cytology; Gene expression; Mammals; Brain cell atlas; Cellular composition; Cerebral cortex; Domestic pigs; Frontal lobes; Neural science; Single cells; Single-cell transcriptome; Temporal lobes; Transcriptomics; Brain
语种	英语
来源期刊	Science Bulletin
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/207696
作者单位	College of Life Sciences, University of Chinese Academy of Sciences, Beijing, 100049, China; BGI-Shenzhen, Shenzhen, 518083, China; MGI, BGI-Shenzhen, Shenzhen, 518083, China; Department of Neurobiology, NHC and CAMS Key Laboratory of Medical Neurobiology, School of Brain Science and Brian Medicine, and the MOE Frontier Science Center for Brain Research and Brain–Machine Integration, Zhejiang University School of Medicine, Hangzhou, 310031, China; State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, 430070, China; College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, China; School of Biological Science & Medical Engineering, Southeast University, Nanjing, 210096, China; School of Basic Medicine, Qingdao University, Qingdao, 266071, China; College of Life Science, South China Agricultural University, Guangzhou, 510642, China; Shenzhen Children's Hospital, Shenzhen, 518083, China; Research Center for Translational Medicine, East Hospital, Ton...
推荐引用方式 GB/T 7714	Zhu J.,Chen F.,Luo L.,et al. Single-cell atlas of domestic pig cerebral cortex and hypothalamus[J],2021,66(14).
APA	Zhu J..,Chen F..,Luo L..,Wu W..,Dai J..,...&Chen D..(2021).Single-cell atlas of domestic pig cerebral cortex and hypothalamus.Science Bulletin,66(14).
MLA	Zhu J.,et al."Single-cell atlas of domestic pig cerebral cortex and hypothalamus".Science Bulletin 66.14(2021).