气候变化领域集成服务门户(CCPortal): Schizophrenia risk-gene Crmp2 deficiency causes precocious critical period plasticity and deteriorated binocular vision

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DOI	10.1016/j.scib.2021.02.011
	Schizophrenia risk-gene Crmp2 deficiency causes precocious critical period plasticity and deteriorated binocular vision
	Zhang Y.; Yao L.; Li X.; Meng M.; Shang Z.; Wang Q.; Xiao J.; Gu X.; Xu Z.; Zhang X.
发表日期	2021
ISSN	20959273
英文摘要	Brain-specific loss of a microtubule-binding protein collapsin response mediator protein-2 (CRMP2) in the mouse recapitulates many schizophrenia-like behaviors of human patients, possibly resulting from associated developmental deficits in neuronal differentiation, path-finding, and synapse formation. However, it is still unclear how the Crmp2 loss affects neuronal circuit function and plasticity. By conducting in vivo and ex vivo electrophysiological recording in the mouse primary visual cortex (V1), we reveal that CRMP2 exerts a key regulation on the timing of postnatal critical period (CP) for experience-dependent circuit plasticity of sensory cortex. In the developing V1, the Crmp2 deficiency induces not only a delayed maturation of visual tuning functions but also a precocious CP for visual input-induced ocular dominance plasticity and its induction activity – coincident binocular inputs right after eye-opening. Mechanistically, the Crmp2 deficiency accelerates the maturation process of cortical inhibitory transmission and subsequently promotes an early emergence of balanced excitatory-inhibitory cortical circuits during the postnatal development. Moreover, the precocious CP plasticity results in deteriorated binocular depth perception in adulthood. Thus, these findings suggest that the Crmp2 deficiency dysregulates the timing of CP for experience-dependent refinement of circuit connections and further leads to impaired sensory perception in later life. © 2021 Science China Press
关键词	Binocular depth perception Collapsin response mediator protein-2 (CRMP2)Critical period plasticity Excitation-inhibition balance Primary visual cortex Schizophrenia
英文关键词	Behavioral research; Binocular vision; Binoculars; Depth perception; Diseases; Electric network analysis; Electrophysiology; Neurons; Timing circuits; Binding proteins; Binocular depth perception; Collapsin response mediator protein-2; Critical period plasticity; Critical periods; Excitation-inhibition balance; Human patients; Microtubules; Neuronal differentiation; Primary visual cortex; Proteins
语种	英语
来源期刊	Science Bulletin
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/207676
作者单位	State Key Laboratory of Cognitive Neuroscience & Learning, IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, 100875, China; State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, 100101, China
推荐引用方式 GB/T 7714	Zhang Y.,Yao L.,Li X.,et al. Schizophrenia risk-gene Crmp2 deficiency causes precocious critical period plasticity and deteriorated binocular vision[J],2021.
APA	Zhang Y..,Yao L..,Li X..,Meng M..,Shang Z..,...&Zhang X..(2021).Schizophrenia risk-gene Crmp2 deficiency causes precocious critical period plasticity and deteriorated binocular vision.Science Bulletin.
MLA	Zhang Y.,et al."Schizophrenia risk-gene Crmp2 deficiency causes precocious critical period plasticity and deteriorated binocular vision".Science Bulletin (2021).