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DOI	10.1016/j.scib.2020.11.001
	The sulfur metabolism regulator MetR is a global regulator controlling phytochrome-dependent light responses in Aspergillus nidulans
	Yu Z.; Gao J.; Igbalajobi O.; Skoneczny M.; Sieńko M.; Maciejewska A.M.; Brzywczy J.; Fischer R.
发表日期	2021
ISSN	20959273
起始页码	592
结束页码	602
卷号	66 期号:6
英文摘要	Phytochrome-dependent light signaling has been studied in several fungi. In Aspergillus nidulans light-stimulated phytochrome activates the high-osmolarity glycerol (HOG) signaling pathway and thereby controls the expression of a large number of genes, many of which are related to stress responses. In a genome-wide expression analysis in A. nidulans we found that phytochrome, fphA, is under strict expression control of the central regulator of the sulfur-starvation response, MetR. This transcriptional regulator is required for the expression of genes involved in inorganic sulfur assimilation. In the presence of organic sulfur, MetR is probably ubiquitinated and possibly degraded and the transcription of sulfur-assimilation genes, e.g., sulfate permease, is turned off. The expression analysis described here revealed, however, that MetR additionally controls the expression of hundreds of genes, many of which are required for secondary metabolite production. We also show that metR mutation phenocopies fphA deletion, and five other histidine-hybrid kinases are down-regulated in the metR1 mutant. Furthermore, we found that light and phytochrome regulate the expression of at least three carbon–sulfur hydrolases. This work is a further step towards understanding the interplay between light sensing and metabolic pathways. © 2020 Science China Press
关键词	Cys3 Met4 Phytochrome Sulfur metabolism Transcriptome
英文关键词	Amino acids; Aspergillus; Enzymes; Metabolism; Metabolites; Sulfur compounds; Transcription; Aspergillus nidulans; Expression analysis; Expression controls; Metabolic pathways; Secondary metabolite production; Signaling pathways; Sulfur starvations; Transcriptional regulator; Sulfur
语种	英语
来源期刊	Science Bulletin
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/207653
作者单位	Department of Microbiology, Institute for Applied Biosciences, Karlsruhe Institute of Technology (KIT)-South Campus, Karlsruhe, D-76131, Germany; The Key Laboratory of Plant Immunity, Jiangsu Provincial Key Lab for Organic Solid Waste Utilization, Jiangsu Collaborative Innovation Center for Solid Organic Waste Resource Utilization, National Engineering Research Center for Organic-based Fertilizers, Nanjing Agricultural University, Nanjing, 210095, China; Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warszawa, 02-106, Poland; Michael Smith Laboratories, Department of Microbiology and Immunology, University of British Columbia, Vancouver, BC VGT 1Z4, Canada
推荐引用方式 GB/T 7714	Yu Z.,Gao J.,Igbalajobi O.,et al. The sulfur metabolism regulator MetR is a global regulator controlling phytochrome-dependent light responses in Aspergillus nidulans[J],2021,66(6).
APA	Yu Z..,Gao J..,Igbalajobi O..,Skoneczny M..,Sieńko M..,...&Fischer R..(2021).The sulfur metabolism regulator MetR is a global regulator controlling phytochrome-dependent light responses in Aspergillus nidulans.Science Bulletin,66(6).
MLA	Yu Z.,et al."The sulfur metabolism regulator MetR is a global regulator controlling phytochrome-dependent light responses in Aspergillus nidulans".Science Bulletin 66.6(2021).