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DOI	10.1016/j.scib.2021.01.002
	Histamine activates HinK to promote the virulence of Pseudomonas aeruginosa
	Wang Y.; Cao Q.; Cao Q.; Gan J.; Sun N.; Yang C.-G.; Bae T.; Wu M.; Lan L.
发表日期	2021
ISSN	20959273
起始页码	1101
结束页码	1118
卷号	66 期号:11
英文摘要	During infections, bacteria stimulate host cells to produce and release histamine, which is a key mediator of vital cellular processes in animals. However, the mechanisms underlying the bacterial cell's ability to sense and respond to histamine are poorly understood. Herein, we show that HinK, a LysR-type transcriptional regulator, is required to evoke responses to histamine in Pseudomonas aeruginosa, an important human pathogen. HinK directly binds to and activates the promoter of genes involved in histamine uptake and metabolism, iron acquisition, and Pseudomonas quinolone signal (PQS) biosynthesis. The transcriptional regulatory activity of HinK is induced when histamine is present, and it occurs when HinK binds with imidazole-4-acetic acid (ImAA), a histamine metabolite whose production in P. aeruginosa depends on the HinK-activated histamine uptake and utilization operon hinDAC-pa0222. Importantly, the inactivation of HinK inhibits diverse pathogenic phenotypes of P. aeruginosa. These results suggest that histamine acts as an interkingdom signal and provide insights into the mechanism used by pathogenic bacteria to exploit host regulatory signals to promote virulence. © 2021 Science China Press
关键词	Histamine Host-microbe interaction Metabolism Pseudomonas aeruginosa Virulence
英文关键词	Biochemistry; Metabolites; Transcription; Bacterial cells; Cellular process; Human pathogens; Iron acquisition; Pathogenic bacterium; Pseudomonas aeruginosa; Regulatory signals; Transcriptional regulator; Bacteria
语种	英语
来源期刊	Science Bulletin
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/207601
作者单位	State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China; College of Life Science, Northwest University, Xi'an, China; University of Chinese Academy of Sciences, No. 19A Yuquan Road, Beijing, 100049, China; State Key Laboratory of Genetic Engineering, Shanghai Public Health Clinical Center, Collaborative Innovation Center of Genetics and Development, School of Life Sciences, Fudan University, Shanghai, 201438, China; The State Key Laboratory of Chemical Biology and Drug Discovery, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong; School of Pharmaceutical Science and Technology, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou, 310024, China; Department of Microbiology and Immunology, Indiana University School of Medicine-Northwest, Gary, IN 46408, United States; Department of Biomedical Sciences, University of North Dakota, Grand Forks, N...
推荐引用方式 GB/T 7714	Wang Y.,Cao Q.,Cao Q.,et al. Histamine activates HinK to promote the virulence of Pseudomonas aeruginosa[J],2021,66(11).
APA	Wang Y..,Cao Q..,Cao Q..,Gan J..,Sun N..,...&Lan L..(2021).Histamine activates HinK to promote the virulence of Pseudomonas aeruginosa.Science Bulletin,66(11).
MLA	Wang Y.,et al."Histamine activates HinK to promote the virulence of Pseudomonas aeruginosa".Science Bulletin 66.11(2021).