气候变化领域集成服务门户(CCPortal): Oncogenic lncRNA LINC00973 promotes warburg effect by enhancing LDHA enzyme activity

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DOI	10.1016/j.scib.2021.01.001
	Oncogenic lncRNA LINC00973 promotes warburg effect by enhancing LDHA enzyme activity
	Wang H.; Lin K.; Zhu L.; Zhang S.; Li L.; Liao Y.; Zhang B.; Yang M.; Liu X.; Li L.; Li S.; Yang L.; Wang H.; Wang Q.; Li H.; Fu S.; Zhang X.; Jiang P.; Zhang Q.C.; Cheng J.; Wang D.
发表日期	2021
ISSN	20959273
英文摘要	Aerobic glycolysis, also known as the Warburg effect, is a hallmark of cancer and essential for metabolism in malignancies, but its regulation and modulation in cancer cells remain poorly understood. Here, using large-scale functional screening, we identified a tumor-associated and broadly expressed oncogenic long noncoding RNA LINC00973. Notably, knocking down LINC00973 significantly inhibits the proliferation of multiple types of cancer cells and reduces tumor growth in vivo. Mechanistically, LINC00973 directly binds to lactate dehydrogenase A (LDHA), an essential glycolytic enzyme, and enhances its enzymatic activity, thereby promoting glycolysis. Clinically, high expression of LINC00973 is significantly associated with poor prognosis in many types of human cancers. This work demonstrates that LINC00973 modulates cancer-specific regulation of the Warburg effect, and may represent a potential target for broad-acting anti-cancer therapies. © 2021 Science China Press
关键词	Biomarker Cancer metabolism LDHA LINC00973 Warburg effect
英文关键词	Cells; Diagnosis; Diseases; Pathology; Tumors; Anti-cancer therapies; Enzymatic activities; Functional screening; Glycolytic enzyme; Lactate dehydrogenase; Non-coding RNAs; Potential targets; Warburg effects; Enzyme activity
语种	英语
来源期刊	Science Bulletin
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/207587
作者单位	School of Medicine, Tsinghua University, Beijing, 100084, China; School of Life Sciences, Tsinghua University, Beijing, 100084, China; Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China; National Engineering Research Center for Beijing Biochip Technology, Beijing, 102206, China; Center for Precision Medicine, West China Hospital, Sichuan University, Chengdu, 610041, China; School of Basic Medical Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, China; State Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, China
推荐引用方式 GB/T 7714	Wang H.,Lin K.,Zhu L.,et al. Oncogenic lncRNA LINC00973 promotes warburg effect by enhancing LDHA enzyme activity[J],2021.
APA	Wang H..,Lin K..,Zhu L..,Zhang S..,Li L..,...&Wang D..(2021).Oncogenic lncRNA LINC00973 promotes warburg effect by enhancing LDHA enzyme activity.Science Bulletin.
MLA	Wang H.,et al."Oncogenic lncRNA LINC00973 promotes warburg effect by enhancing LDHA enzyme activity".Science Bulletin (2021).