气候变化领域集成服务门户(CCPortal): Ecology of avian influenza viruses in migratory birds wintering within the Yangtze River wetlands

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DOI	10.1016/j.scib.2021.03.023
	Ecology of avian influenza viruses in migratory birds wintering within the Yangtze River wetlands
	Wang D.; Li M.; Xiong C.; Yan Y.; Hu J.; Hao M.; Liang B.; Chen J.; Chen G.; Yang G.; Li Y.; Zhang J.; Gulyaeva M.; Shestopalov A.; Shi W.; Bi Y.; Liu H.; Wang H.; Liu D.; Chen J.
发表日期	2021
ISSN	20959273
英文摘要	Migratory birds are considered natural reservoirs of avian influenza A viruses (AIVs). To further our viral ecology knowledge and understand the subsequent risk posed by wild birds, we conducted a 4-year surveillance study of AIVs in the bird wintering wetlands of the Yangtze River, China. We collected over 8000 samples and isolated 122 AIV strains. Analyses were then carried out with 108 novel sequenced genomes and data were deposited in GISAID and other public databases. The results showed that the Yangtze River wintering wetlands functioned as a mixing ground, where various subtypes of AIVs were detected harboring a high diversity of nucleotide sequences; moreover, a portion of AIV gene segments were persistent inter-seasonally. Phylogenetic incongruence presented complex reassortment events and distinct patterns among various subtypes. In addition, we observed that viral gene segments in wintering wetlands were closely related to known North American isolates, indicating that intercontinental gene flow occurred. Notably, highly pathogenic H5 and low pathogenic H9 viruses, which usually circulate in poultry, were found to have crossed the poultry/wild bird interface, with the viruses introduced to wintering birds. Overall, this study represented the largest AIV surveillance effort of wild birds within the Yangtze River wintering wetlands. Surveillance data highlighted the important role of wintering wild birds in the ecology of AIVs and may enable future early warnings of novel AIV emergence. © 2021 Science China Press
关键词	Avian influenza viruses Migratory birds Yangtze River wetlands
英文关键词	Birds; Ecology; Genes; Monitoring; Rivers; Wetlands; Avian influenza; Avian influenza virus; Influenza A virus; Migratory birds; Pathogenics; Public database; Virus strains; Wild birds; Yangtze River; Yangtze river wetland; Viruses
语种	英语
来源期刊	Science Bulletin
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/207583
作者单位	CAS Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, 430071, China; National Virus Resource Center, Chinese Academy of Sciences, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Wuhan, 430071, China; University of Chinese Academy of Sciences, Beijing, 100049, China; Hubei Wildlife Rescue, Research and Development Center, Wuhan, 430074, China; Novosibirsk State University, Novosibirsk, 630090, Russian Federation; Federal Research Center of Fundamental and Translational Medicine, Novosibirsk, 630117, Russian Federation; Key Laboratory of Etiology and Epidemiology of Emerging Infectious Diseases in Universities of Shandong, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian, 271000, China; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Disease, Institute of Microbiology, Chines...
推荐引用方式 GB/T 7714	Wang D.,Li M.,Xiong C.,et al. Ecology of avian influenza viruses in migratory birds wintering within the Yangtze River wetlands[J],2021.
APA	Wang D..,Li M..,Xiong C..,Yan Y..,Hu J..,...&Chen J..(2021).Ecology of avian influenza viruses in migratory birds wintering within the Yangtze River wetlands.Science Bulletin.
MLA	Wang D.,et al."Ecology of avian influenza viruses in migratory birds wintering within the Yangtze River wetlands".Science Bulletin (2021).