气候变化领域集成服务门户(CCPortal): The role of iron homeostasis in remodeling immune function and regulating inflammatory disease

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DOI	10.1016/j.scib.2021.02.010
	The role of iron homeostasis in remodeling immune function and regulating inflammatory disease
	Mu Q.; Chen L.; Gao X.; Shen S.; Sheng W.; Min J.; Wang F.
发表日期	2021
ISSN	20959273
起始页码	1806
结束页码	1816
卷号	66 期号:17
英文摘要	The essential trace element iron regulates a wide range of biological processes in virtually all living organisms. Because both iron deficiency and iron overload can lead to various pathological conditions, iron homeostasis is tightly regulated, and understanding this complex process will help pave the way to developing new therapeutic strategies for inflammatory disease. In recent years, significant progress has been made with respect to elucidating the roles of iron and iron-related genes in the development and maintenance of the immune system. Here, we review the timing and mechanisms by which systemic and cellular iron metabolism are regulated during the inflammatory response and during infectious disease, processes in which both the host and the pathogen compete for iron. We also discuss the evidence and implications that immune cells such as macrophages, T cells, and B cells require sufficient amounts of iron for their proliferation and for mediating their effector functions, in which iron serves as a co-factor in toll-like receptor 4 (TLR4) signaling, mitochondrial respiration, posttranslational regulation, and epigenetic modification. In addition, we discuss the therapeutic implications of targeting ferroptosis, iron homeostasis and/or iron metabolism with respect to conferring protection against pathogen infection, controlling inflammation, and improving the efficacy of immunotherapy. © 2021 Science China Press
关键词	Anemia of inflammation Ferroptosis Inflammatory response Iron homeostasis Iron overload
英文关键词	Cell signaling; Diseases; Metabolism; Pathology; Trace elements; Anemia of inflammation; Biological process; Ferroptosis; Immune function; Inflammatory disease; Inflammatory response; Iron homeostasis; Iron metabolism; Iron overloads; Traces elements; Iron
语种	英语
来源期刊	Science Bulletin
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/207528
作者单位	The First Affiliated Hospital, Institute of Translational Medicine, School of Public Health, Zhejiang University School of Medicine, Hangzhou, 310058, China; Hengyang Medical School, University of South China, Hengyang, 421001, China
推荐引用方式 GB/T 7714	Mu Q.,Chen L.,Gao X.,et al. The role of iron homeostasis in remodeling immune function and regulating inflammatory disease[J],2021,66(17).
APA	Mu Q..,Chen L..,Gao X..,Shen S..,Sheng W..,...&Wang F..(2021).The role of iron homeostasis in remodeling immune function and regulating inflammatory disease.Science Bulletin,66(17).
MLA	Mu Q.,et al."The role of iron homeostasis in remodeling immune function and regulating inflammatory disease".Science Bulletin 66.17(2021).