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| DOI | 10.1016/j.scib.2021.02.018 |
| Low levels of low-density lipoprotein cholesterol and cognitive decline | |
| Hua R.; Ma Y.; Li C.; Zhong B.; Xie W. | |
| 发表日期 | 2021 |
| ISSN | 20959273 |
| 起始页码 | 1684 |
| 结束页码 | 1690 |
| 卷号 | 66期号:16 |
| 英文摘要 | The relationship between low levels of serum low-density lipoprotein cholesterol (LDL-C) and subsequent cognitive decline remains unclear. The present study aimed to evaluate the longitudinal association between low LDL-C levels and cognition decline in the context of the current aggressive guideline-recommended targets (LDL-C levels less than 55 mg/dL for individuals at very high risk of cardiovascular events, and less than 70 mg/dL for high risk individuals). Data from wave 13 (2016) to wave 14 (2018) of the Health and Retirement Study (HRS) were utilized. LDL-C concentrations measured at wave 13 were categorized into 5 levels, reflecting currently recommended values for lipid lowering treatment. Of 7129 included participants (mean age: 69.0 ± 9.9 years, 60.3% female), we found that compared to participants with LDL-C levels of 70.0–99.9 mg/dL, those with LDL-C levels of <55 mg/dL had significantly slower 2-year decline rates in global cognitive function (0.244 point/year; 95% confidence interval (CI): 0.065−0.422; P = 0.008), working memory (0.068 point/year; 95% CI: 0.004−0.133; P = 0.038), and borderline significantly in episodic memory (0.155 point/year; 95% CI: −0.004−0.315; P = 0.057). Similarly, significantly slower decline rates were observed in those with LDL-C levels of 55.0–69.9 mg/dL. The present study demonstrated that compared with LDL-C levels 70.0–99.9 mg/dL, low LDL-C levels (<70 mg/dL, especially <55 mg/dL) were associated with significantly slower cognitive decline in population-based setting. Future randomized controlled trials are warranted to ascertain the safety and benefit of current aggressive guideline-recommended targets on cognitive function. © 2021 |
| 关键词 | Cognitive declineLongitudinal cohort studyLow-density lipoprotein cholesterolThe Health and Retirement Study |
| 英文关键词 | Brain; Cholesterol; Lipoproteins; Cardiovascular event; Cognitive decline; Cognitive functions; Confidence interval; High-risk individuals; Low density lipoproteins; Randomized controlled trial; Recommended values; Population statistics |
| 语种 | 英语 |
| 来源期刊 | Science Bulletin
 |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://gcip.llas.ac.cn/handle/2XKMVOVA/207429 |
| 作者单位 | Heart and Vascular Health Research Center, Peking University Clinical Research Institute, Peking University First Hospital, Beijing, 100191, China; Key Laboratory of Molecular Cardiovascular Sciences (Peking University), Ministry of Education, Beijing, 100191, China; Department of Geriatric Psychiatry, Affiliated Wuhan Mental Health Center, Tongji Medical College of Huazhong University of Science & Technology, Wuhan, 430030, China |
| 推荐引用方式 GB/T 7714 | Hua R.,Ma Y.,Li C.,et al. Low levels of low-density lipoprotein cholesterol and cognitive decline[J],2021,66(16). |
| APA | Hua R.,Ma Y.,Li C.,Zhong B.,&Xie W..(2021).Low levels of low-density lipoprotein cholesterol and cognitive decline.Science Bulletin,66(16). |
| MLA | Hua R.,et al."Low levels of low-density lipoprotein cholesterol and cognitive decline".Science Bulletin 66.16(2021). |
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