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DOI	10.1016/j.scib.2021.01.003
	Pairwise interactions in gene expression determine a hierarchical transcriptional profile in the human brain
	Hua J.; Yang Z.; Jiang T.; Yu S.
发表日期	2021
ISSN	20959273
起始页码	1437
结束页码	1447
卷号	66 期号:14
英文摘要	The orchestrated expression of thousands of genes gives rise to the complexity of the human brain. However, the structures governing these myriad gene-gene interactions remain unclear. By analyzing transcription data from more than 2000 sites in six human brains, we found that pairwise interactions between genes, without considering any higher-order interactions, are sufficient to predict the transcriptional pattern of the genome for individual brain regions and the transcriptional profile of the entire brain consisting of more than 200 areas. These findings suggest a quadratic complexity of transcriptional patterns in the human brain, which is much simpler than expected. In addition, using a pairwise interaction model, we revealed that the strength of gene-gene interactions in the human brain gives rise to the nearly maximal number of transcriptional clusters, which may account for the functional and structural richness of the brain. © 2021 Science China Press
关键词	Co-expression Functional network Gene-gene interaction Higher-order interactions Structural network
英文关键词	Complex networks; Transcription; Co-expression; Functional network; Gene-gene interaction; Genes expression; High-order; High-order interaction; Higher-order; Human brain; Pairwise interaction; Structural networks; Brain
语种	英语
来源期刊	Science Bulletin
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/207428
作者单位	Brainnetome Center and National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing, 100190, China; School of Artificial Intelligence, University of Chinese Academy of Sciences, Beijing, 100049, China; CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Beijing, 100190, China; School of Future Technology, University of Chinese Academy of Sciences, Beijing, 100049, China
推荐引用方式 GB/T 7714	Hua J.,Yang Z.,Jiang T.,et al. Pairwise interactions in gene expression determine a hierarchical transcriptional profile in the human brain[J],2021,66(14).
APA	Hua J.,Yang Z.,Jiang T.,&Yu S..(2021).Pairwise interactions in gene expression determine a hierarchical transcriptional profile in the human brain.Science Bulletin,66(14).
MLA	Hua J.,et al."Pairwise interactions in gene expression determine a hierarchical transcriptional profile in the human brain".Science Bulletin 66.14(2021).