气候变化领域集成服务门户(CCPortal): Polypeptide nanoformulation-induced immunogenic cell death and remission of immunosuppression for enhanced chemoimmunotherapy

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DOI	10.1016/j.scib.2020.07.013
	Polypeptide nanoformulation-induced immunogenic cell death and remission of immunosuppression for enhanced chemoimmunotherapy
	Feng X.; Xu W.; Liu J.; Li D.; Li G.; Ding J.; Chen X.
发表日期	2021
ISSN	20959273
起始页码	362
结束页码	373
卷号	66 期号:4
英文摘要	Many conventional chemotherapeutics play an immune-modulating effect by inducing immunogenic cell death (ICD) in tumor cells. However, they hardly arouse strong antitumor immune response because the immunosuppressive lymphocytes are present in the tumor microenvironment. These immunosuppressive lymphocytes include regulatory T cells (Tregs) and myeloid-derived suppressor cells (MDSCs). We used a low dose of doxorubicin (DOX) to induce ICD in combination with immune regulator 1-methyl-DL-tryptophan (1MT) to suppress indoleamine 2,3-dioxygenase and overcome Treg- and MDSC-associated immune suppression. By co-encapsulation of DOX and 1MT into a reduction-responsive polypeptide nanogel, the drugs were simultaneously released in the tumor cells and synergistically performed antitumor efficacy. After treatment, recruitment of Tregs and MDSCs was inhibited, and the frequency of tumor-infiltrating CD8+ T cells was remarkably enhanced. These results demonstrated that the chemoimmunotherapy strategy effectively suppressed tumor growth without causing evident adverse effects, indicating its great potential in clinical cancer therapy. © 2020 Science China Press
关键词	Chemoimmunotherapy Controlled drug release Immunogenic cell death Polypeptide nanogel Remission of Immunosuppression
英文关键词	T-cells; Tumors; Anti-tumor efficacy; Anti-tumor immune; Co-encapsulation; Immune suppression; Immune-modulating effects; Indoleamine 2 ,3-dioxygenase; Regulatory t cells; Tumor microenvironment; Cell death
语种	英语
来源期刊	Science Bulletin
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/207400
作者单位	Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China; School of Applied Chemistry and Engineering, University of Science and Technology of China, Hefei, 230026, China
推荐引用方式 GB/T 7714	Feng X.,Xu W.,Liu J.,et al. Polypeptide nanoformulation-induced immunogenic cell death and remission of immunosuppression for enhanced chemoimmunotherapy[J],2021,66(4).
APA	Feng X..,Xu W..,Liu J..,Li D..,Li G..,...&Chen X..(2021).Polypeptide nanoformulation-induced immunogenic cell death and remission of immunosuppression for enhanced chemoimmunotherapy.Science Bulletin,66(4).
MLA	Feng X.,et al."Polypeptide nanoformulation-induced immunogenic cell death and remission of immunosuppression for enhanced chemoimmunotherapy".Science Bulletin 66.4(2021).