气候变化领域集成服务门户(CCPortal): Characterization of exploratory patterns and hippocampal–prefrontal network oscillations during the emergence of free exploration

CCPortal

DOI	10.1016/j.scib.2021.05.018
	Characterization of exploratory patterns and hippocampal–prefrontal network oscillations during the emergence of free exploration
	Dong W.; Chen H.; Sit T.; Han Y.; Song F.; Vyssotski A.L.; Gross C.T.; Si B.; Zhan Y.
发表日期	2021
ISSN	20959273
英文摘要	During free exploration, the emergence of patterned and sequential behavioral responses to an unknown environment reflects exploration traits and adaptation. However, the behavioral dynamics and neural substrates underlying the exploratory behavior remain poorly understood. We developed computational tools to quantify the exploratory behavior and performed in vivo electrophysiological recordings in a large arena in which mice made sequential excursions into unknown territory. Occupancy entropy was calculated to characterize the cumulative and moment-to-moment behavioral dynamics in explored and unexplored territories. Local field potential analysis revealed that the theta activity in the dorsal hippocampus (dHPC) was highly correlated with the occupancy entropy. Individual dHPC and prefrontal cortex (PFC) oscillatory activities could classify various aspects of free exploration. Initiation of exploration was accompanied by a coordinated decrease and increase in theta activity in PFC and dHPC, respectively. Our results indicate that dHPC and PFC work synergistically in shaping free exploration by modulating exploratory traits during emergence and visits to an unknown environment. © 2021 Science China Press
关键词	Entropy Exploration Hippocampus Neural oscillations Prefrontal cortex
语种	英语
来源期刊	Science Bulletin
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/207388
作者单位	Guangdong Provincial Key Laboratory of Brain Connectome and Behavior, CAS Key Laboratory of Brain Connectome and Manipulation, the Brain Cognition and Brain Disease Institute (BCBDI), Shenzhen Key Laboratory of Translational Research for Brain Diseases, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions, Shenzhen, 518055, China; State Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy of Sciences, Shenyang, 110016, China; Institutes for Robotics and Intelligent Manufacturing, Chinese Academy of Sciences, Shenyang, 110169, China; University of Chinese Academy of Sciences, Beijing, 100049, China; Institute of Neuroinformatics, the University of Zürich and Swiss Federal Institute of Technology (ETH), Zurich, CH-8057, Switzerland; European Molecular Biology Laboratory (EMBL), Monterotondo, 00015, Italy; School of Systems Science, Beijing Normal University, Beijing, 100875, ...
推荐引用方式 GB/T 7714	Dong W.,Chen H.,Sit T.,等. Characterization of exploratory patterns and hippocampal–prefrontal network oscillations during the emergence of free exploration[J],2021.
APA	Dong W..,Chen H..,Sit T..,Han Y..,Song F..,...&Zhan Y..(2021).Characterization of exploratory patterns and hippocampal–prefrontal network oscillations during the emergence of free exploration.Science Bulletin.
MLA	Dong W.,et al."Characterization of exploratory patterns and hippocampal–prefrontal network oscillations during the emergence of free exploration".Science Bulletin (2021).