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DOI	10.1016/j.scib.2019.11.006
	The pre-existing cellular immunity to Japanese encephalitis virus heterotypically protects mice from Zika virus infection
	Zhang W.; Xu Y.; Zhao F.; Tarbe M.; Zhou S.; Wang W.; Zhang S.; Zhang W.; Xu Q.; Shi L.; Yuan F.; Lin X.; Liu S.; Sun J.; Zhao J.; Yang Y.; Liang X.; Zhong J.; Long G.; Qin C.; Leng Q.; Tang H.
发表日期	2020
ISSN	20959273
起始页码	402
结束页码	409
卷号	65 期号:5
英文摘要	Zika virus (ZIKV) and Japanese encephalitis virus (JEV) are closely related flaviviruses, ZIKV circulates in the population that has been JEV vaccinated in Southeast Asian countries. This alerts that a pre-existing immunity to JEV would impact ZIKV infection and/or pathogenesis. Herein we showed that the pre-existing immunity to JEV SA14-14-2 vaccination provided an ample protection against non-lethal or lethal dose of ZIKV infection in mice. This was in sharp contrast to the passive immunization of JEV antibodies, which failed to affect ZIKV infection or pathogenesis in mice, albeit these antibodies exhibited cross-reactivity and antibody dependent enhancement (ADE) of ZIKV infection in vitro. Furthermore, we determined that JEV vaccine-elicited CD8+ T cells were required to mediate the heterotypic protection of ZIKV infection, which cross-reacted to ZIKV E and NS5 antigens (E294-302 and NS52839-2848). Adoptive transfer of these CD8+ T cells could partially protect the mice from ZIKV challenge. Therefore, although short of epidemiological evidence, these results suggested that cross-reactive CD8+ T cells activated by JEV vaccination could protect potential ZIKV infection in human populations. © 2019
关键词	CD8+ T Cross protection Japanese encephalitis virus Zika virus
英文关键词	Antibodies; Mammals; Vaccines; Viruses; Antibody-dependent enhancements; CD8^+T; Cross protection; Cross reactivity; Human population; Japanese encephalitis virus; Japanese encephalitis viruses (JEV); Passive immunization; T-cells
语种	英语
来源期刊	Science Bulletin
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/207301
作者单位	State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, 430071, China; CAS Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, 200031, China; CAS Key Laboratory of Infection and Immunity, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China; State Key Laboratory of Respiratory Diseases, Affiliated Cancer Hospital & Institute of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, 510095, China; Shanghai Public Health Clinical Center, Fudan University, Shanghai, 201508, China; Department of Virology, State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, 100071, China; University of Chinese Academy of Sciences, Beijing, 100049, China
推荐引用方式 GB/T 7714	Zhang W.,Xu Y.,Zhao F.,et al. The pre-existing cellular immunity to Japanese encephalitis virus heterotypically protects mice from Zika virus infection[J],2020,65(5).
APA	Zhang W..,Xu Y..,Zhao F..,Tarbe M..,Zhou S..,...&Tang H..(2020).The pre-existing cellular immunity to Japanese encephalitis virus heterotypically protects mice from Zika virus infection.Science Bulletin,65(5).
MLA	Zhang W.,et al."The pre-existing cellular immunity to Japanese encephalitis virus heterotypically protects mice from Zika virus infection".Science Bulletin 65.5(2020).