气候变化领域集成服务门户(CCPortal): Immunotherapeutic silk inverse opal particles for post-surgical tumor treatment

CCPortal

DOI	10.1016/j.scib.2019.10.023
	Immunotherapeutic silk inverse opal particles for post-surgical tumor treatment
	Zhang H.; Liu Y.; Chen G.; Wang H.; Chen C.; Li M.; Lu P.; Zhao Y.
发表日期	2020
ISSN	20959273
起始页码	380
结束页码	388
卷号	65 期号:5
英文摘要	Recurrence of malignant tumor after surgical resection is the main reason of cancer treatment failure. Here, a novel kind of silk inverse opal particles (SIOPs) for post-surgical tumor treatment is presented, and it is derived from colloid crystal bead templates by negatively replicating. Because of their abundant uniform nanopores, interconnected nanochannels and excellent biocompatibility, SIOPs could not only carry great amount of anti-tumor drugs for tumor therapy, but also could provide support for cell adhesion, proliferation and differentiation as the 3D spherical scaffolds which is beneficial to the tissue repair at resection sites. It is demonstrated that the antibody drugs could maintain their high biological activity without any influences during the preparation of SIOPs and these particles were able to enhance the therapeutic efficacy and promote tissue regeneration after surgical resection with their multifunctional features. These prominent properties indicate the great potentials of SIOPs as a promising strategy for efficient postoperative cancer therapy. © 2019 Science China Press
关键词	Biomaterial Drug delivery Hydrogel Inverse opal Silk fibroin Tumor immunology
英文关键词	Bioactivity; Biocompatibility; Biomaterials; Cell adhesion; Diseases; Drug delivery; Hydrogels; Scaffolds (biology); Surgery; Tissue regeneration; Colloid crystals; Immunotherapeutic; Inverse opal; Silk fibroin; Surgical resection; Therapeutic efficacy; Treatment failure; Tumor immunologies; Tumors
语种	英语
来源期刊	Science Bulletin
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/207293
作者单位	State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing, 210096, China; Department of Medical Oncology, Wuxi People's Hospital, Nanjing Medical University, Wuxi, 214023, China; Department of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing, 210002, China
推荐引用方式 GB/T 7714	Zhang H.,Liu Y.,Chen G.,et al. Immunotherapeutic silk inverse opal particles for post-surgical tumor treatment[J],2020,65(5).
APA	Zhang H..,Liu Y..,Chen G..,Wang H..,Chen C..,...&Zhao Y..(2020).Immunotherapeutic silk inverse opal particles for post-surgical tumor treatment.Science Bulletin,65(5).
MLA	Zhang H.,et al."Immunotherapeutic silk inverse opal particles for post-surgical tumor treatment".Science Bulletin 65.5(2020).