气候变化领域集成服务门户(CCPortal): Cathepsin C promotes the progression of periapical periodontitis

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DOI	10.1016/j.scib.2019.12.006
	Cathepsin C promotes the progression of periapical periodontitis
	Yin W.; Dong M.; Ye D.; Liu Q.; Liu S.; Shi C.; Bai H.; Wang Q.; Yang X.; Wang L.; Niu W.
发表日期	2020
ISSN	20959273
起始页码	951
结束页码	957
卷号	65 期号:11
英文摘要	Although the role of cathepsin C (Cat C) in inflammation is gradually being elucidated, its function in periapical periodontitis, which is one of the most common infectious diseases worldwide, has not been studied. This study evaluated a surgically-induced model of periapical periodontitis in cathepsin C (Cat C) knock-down (KD) mice, which was constructed with a tetracycline operator, to evaluate the role of Cat C in the pathogenesis and progression of periapical periodontitis. Our results showed, for the first time, that there was a statistically significant increase in the expression of Cat C as periapical periodontitis progressed; this increase started from 1 week after surgery and reached a peak at 3 weeks after surgery, before gradually decreasing. The volume of periapical bone resorption in Cat C KD mice was significantly smaller than that in wild-type mice at 3 and 4 weeks after surgery (P<0.05). Inflammatory cell infiltration into the apical tissues of wild-type mice was also significantly higher than that of Cat C KD mice. The expression of receptor activator of nuclear factor-κB ligand (RANKL) in wild-type mice was also higher than that in Cat C KD mice. The difference in the number of osteoclasts in the apical area between the two groups was statistically significant after 2 weeks. Correlation analysis showed that there was a significant correlation between Cat C and RANKL expression (r= 0.835). Therefore, our data indicated that Cat C promoted the apical inflammation and bone destruction in mice. © 2019 Science China Press
关键词	Cathepsin C Periapical periodontitis Receptor activator of nuclear factor-κB ligand Tartrate resistant acid phosphatase
英文关键词	Bone; Ligands; Mammals; Pathology; Phosphatases; Surgery; Correlation analysis; Infectious disease; Inflammatory cells; Nuclear factor kappaB; Nuclear factors; Periapical periodontitis; Receptor activator; Tartrate-resistant acid phosphatase; Diseases
语种	英语
来源期刊	Science Bulletin
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/207276
作者单位	The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory of Oral Biomedicine (Ministry of Education), School & Hospital of Stomatology, Wuhan University, Wuhan, 430079, China; Department of Biomedical Data Science, Geisel School of Medicine at Dartmouth College, One Medical Center Drive, Lebanon, NH 03756, United States; School of Stomatology, Dalian Medical University, Dalian, 116044, China; Hospital of Stomatology, Yiwu City, Jinhua 322005, China
推荐引用方式 GB/T 7714	Yin W.,Dong M.,Ye D.,et al. Cathepsin C promotes the progression of periapical periodontitis[J],2020,65(11).
APA	Yin W..,Dong M..,Ye D..,Liu Q..,Liu S..,...&Niu W..(2020).Cathepsin C promotes the progression of periapical periodontitis.Science Bulletin,65(11).
MLA	Yin W.,et al."Cathepsin C promotes the progression of periapical periodontitis".Science Bulletin 65.11(2020).