气候变化领域集成服务门户(CCPortal): Salience processing by glutamatergic neurons in the ventral pallidum

CCPortal

DOI	10.1016/j.scib.2019.11.029
	Salience processing by glutamatergic neurons in the ventral pallidum
	Wang F.; Zhang J.; Yuan Y.; Chen M.; Gao Z.; Zhan S.; Fan C.; Sun W.; Hu J.
发表日期	2020
ISSN	20959273
起始页码	389
结束页码	401
卷号	65 期号:5
英文摘要	Organisms must make sense of a constant stream of sensory inputs from both internal and external sources which compete for attention by determining which ones are salient. The ability to detect and respond appropriately to potentially salient stimuli in the environment is critical to all organisms. However, the neural circuits that process salience are not fully understood. Here, we identify a population of glutamatergic neurons in the ventral pallidum (VP) that play a unique role in salience processing. Using cell-type-specific fiber photometry, we find that VP glutamatergic neurons are robustly activated by a variety of aversion- and reward-related stimuli, as well as novel social and non-social stimuli. Inhibition of the VP glutamatergic neurons reduces the ability to detect salient stimuli in the environment, such as aversive cue, novel conspecific and novel object. Besides, VP glutamatergic neurons project to both the lateral habenula (LHb) and the ventral tegmental area (VTA). Together, our findings demonstrate that the VP glutamatergic neurons participate in salience processing and therefore provide a new perspective on treating several neuropsychiatric disorders, including dementia and psychosis. © 2019
关键词	Aversion Glutamate Novelty Reward Salience Ventral pallidum (VP)
英文关键词	Aversion; Glutamate; Novelty; Reward; Salience; Ventral pallidum (VP); Neurons
语种	英语
来源期刊	Science Bulletin
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/207202
作者单位	School of Life Science and Technology, ShanghaiTech University, Shanghai, 201210, China; Institute of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, 200031, China; University of Chinese Academy of Sciences, Beijing, 100049, China; Columbia University, New York, NY 10027, United States; iHuman Institute, ShanghaiTech University, Shanghai, 201210, China; Chinese Institute for Brain Research, Beijing, 102206, China; School of Basic Medical Sciences, Capital Medical University, Beijing, 100069, China; Co-innovation Center of Neuroregeneration, Nantong University, Nantong, 226019, China
推荐引用方式 GB/T 7714	Wang F.,Zhang J.,Yuan Y.,et al. Salience processing by glutamatergic neurons in the ventral pallidum[J],2020,65(5).
APA	Wang F..,Zhang J..,Yuan Y..,Chen M..,Gao Z..,...&Hu J..(2020).Salience processing by glutamatergic neurons in the ventral pallidum.Science Bulletin,65(5).
MLA	Wang F.,et al."Salience processing by glutamatergic neurons in the ventral pallidum".Science Bulletin 65.5(2020).